Pfam Domains mapped on to the structure: 2HAE

No.	Chain ID	Pfam ID	Pfam Description	Linkout - Pfam	Linkout - CDD
1	A	PF00390	Malic enzyme, N-terminal domain	PF00390	PF00390
2	A	PF00390	Malic enzyme, N-terminal domain	PF00390	PF00390
3	A	PF00208	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase	PF00208	PF00208
4	A	PF03949	Malic enzyme, NAD binding domain	PF03949	PF03949

Gene Ontology Annotations: 2HAE

No.	GO ID	GO Description	Linkout - AmiGO
1	GO:0055114	oxidation-reduction process	GO:0055114

Conserved Domain Database Superfamily Annotations: 2HAE

No.	PDB ID	PSSM ID	CDD Accession	Superfamily Short Name	Linkout - CDD
1	2HAE	133453	cd05311	NAD_bind_2_malic_enz -	cl09931
2	2HAE	212616	cl09931	NADB_Rossmann	superfamily - -
3	2HAE	201200	cl02855	malic	superfamily - -

Structural Details of PDB entry 2HAE PDBid Chains Hinge Swapped Domain 2HAE A,B A:17-24,B:17-24;A:47-58,B:47-58 A:25-46,B:25-46 Swapped-domain interface residues and interactions: Chains Residues A 25, 28, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, C 2, 3, 4, 75, 78, 79, 82, 83, 86, Non-swapped-domain interface residues and interactions: Chains Residues A 2, 3, 4, 6, 7, 8, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 23, 24, 47, 50, 52, 53, 54, 55, 56, 57, 59, 70, 72, 75, 78, 79, 81, 82, 83, 85, 86, 87, 89, 90, 92, 93, 94, 98, 99, 100, 101, 102, 103, 104, 105, 115, 118, 119, 120, 121, 122, 123, 306, 360, 376, C 6, 7, 8, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 23, 25, 28, 30, 31, 32, 33, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 47, 50, 52, 53, 54, 55, 56, 57, 59, 70, 72, 81, 85, 87, 89, 90, 92, 93, 94, 98, 99, 100, 101, 102, 103, 104, 105, 115, 118, 119, 120, 121, 122, 123, 305, 306, 315, 360,

Swapped domains are represented using trasperent spheres. Non-swapped part is represented using light color and cartoon representation. Hinge region is shown in yellow color.

Mutations in critical regions:

Chains	Hinge	Domain swapped interface	Non-swapped interface	Swapped Domain
A	No mutation	No mutation	LEU(6)ILE,	No mutation
B	No mutation	No mutation	No mutation	No mutation
B	No mutation	No mutation	No mutation	No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:2HAE

C:2HAE

JOY Structural annotation for hinge hinge and swapped domain:

Hinge	Swapped domain

JOY output:

ali file:	2HAE.ali
atm file:	2HAE.atm
cof file:	2HAE.cof
hbd file:	2HAE.hbd
html file:	2HAE.html
pdb file:	2HAE.pdb
ps file:	2HAE.ps
psa file:	2HAE.psa
rtf file:	2HAE.rtf
sst file:	2HAE.sst
tem file:	2HAE.tem