3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 2H46

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 E PF00017 SH2 domain PF00017 PF00017

Conserved Domain Database Superfamily Annotations: 2H46

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 2H46 199828 cd09941 SH2_Grb2_like - cl15255

2 2H46 210054 cl15255 SH2 superfamily - -

3 2H46 210054 cl15255 SH2 superfamily - -

Structural Details of PDB entry 2H46

Structural Details of PDB entry 2H46

PDBid Chains Hinge Swapped Domain

2H46 F,A,E,B,H,C,D,G F:121-123,A:121-123,E:121-123,B:121-123,H:121-123,C:121-123,D:121-123,G:121-123 F:124-152,A:124-152,E:124-152,B:124-152,H:124-152,C:124-152,D:124-152,G:124-152

Swapped-domain interface residues and interactions:

Chains Residues
A 77, 81, 82, 83, 117, 118, 119, 120, 124, 125, 126, 127, 128, 129, 131, 132, 135, 136, 138, 139, 140, 141, 142, 144, 145, 146, 147, 148, 149, 150, 151, 152,

B 77, 81, 82, 83, 117, 118, 119, 120, 124, 125, 126, 127, 128, 129, 131, 132, 135, 136, 138, 139, 140, 141, 142, 144, 145, 146, 147, 148, 149, 150, 151,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 58, 59, 60, 73, 78, 79, 80, 85, 95, 97, 99, 101, 106, 108, 110, 113, 121, 122, 123,

B 58, 59, 60, 73, 78, 79, 80, 85, 95, 97, 99, 101, 106, 108, 110, 113, 121, 122, 123,

Swapped domains are represented using trasperent spheres.
Non-swapped part is reprented using light color and cartoon reprentation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

F No mutation No mutation No mutation No mutation

A No mutation No mutation No mutation No mutation

E No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

H No mutation No mutation No mutation No mutation

C No mutation No mutation No mutation No mutation

D No mutation No mutation No mutation No mutation

G No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

F:2H46 G:2H46 H:2H46 E:2H46 3:2H46 A:2H46 B:2H46 C:2H46 D:2H46

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 2H46.ali
atm file: 2H46.atm
cof file: 2H46.cof
hbd file: 2H46.hbd
html file: 2H46.html
pdb file: 2H46.pdb
ps file: 2H46.ps
psa file: 2H46.psa
rtf file: 2H46.rtf
sst file: 2H46.sst
tem file: 2H46.tem