Pfam Domains mapped on to the structure: 2GZA

No.	Chain ID	Pfam ID	Pfam Description	Linkout - Pfam	Linkout - CDD
1	A	PF00437	Type II/IV secretion system protein	PF00437	PF00437

Gene Ontology Annotations: 2GZA

No.	GO ID	GO Description	Linkout - AmiGO
1	GO:0005622	intracellular	GO:0005622

Conserved Domain Database Superfamily Annotations: 2GZA

No.	PDB ID	PSSM ID	CDD Accession	Superfamily Short Name	Linkout - CDD
1	2GZA	29996	cd01130	VirB11-like_ATPase -	cl09099
2	2GZA	212613	cl09099	P-loop_NTPase	superfamily - -
3	2GZA	212613	cl09099	P-loop_NTPase	superfamily - -

Structural Details of PDB entry 2GZA PDBid Chains Hinge Swapped Domain 2GZA F,A,D,C,E,B F:136-150,A:121-128,D:136-150,C:121-128,E:136-150,B:121-128;A:137-150,C:137-150,B:137-150 F:151-353,A:129-136,D:151-353,C:129-136,E:151-353,B:129-136 Swapped-domain interface residues and interactions: Chains Residues A 129, 130, 132, 133, 183, 184, 285, 286, 287, 291, 301, 302, B 129, 130, 132, 133, 165, 194, C 54, 55, 127, 128, 129, 130, 132, 133, 137, 138, 140, 141, 143, 144, 165, 194, 249, 274, 275, 276, 305, 308, 309, 354, D 164, 165, 168, 169, 173, 174, 175, 183, 184, 185, 189, 190, 191, 193, 194, 197, 198, 210, 211, 212, 213, 215, 217, 228, 249, 250, 252, 254, 260, 262, 267, 271, 274, 275, 276, 277, 285, 286, 287, 290, 291, 294, 295, 298, 301, 302, 305, 307, 308, 309, 310, 311, 313, 315, 316, 317, 320, 330, 332, 333, 334, 336, 338, 339, 340, 341, 342, E 99, 122, 123, 124, 125, 126, 127, 128, 129, 137, 138, 140, 141, 142, 151, 164, 165, 168, 169, 175, 183, 184, 185, 189, 190, 191, 193, 194, 197, 198, 210, 211, 212, 213, 215, 228, 249, 250, 252, 262, 267, 271, 274, 275, 276, 277, 285, 286, 287, 290, 291, 294, 295, 298, 301, 302, 304, 305, 307, 308, 309, 310, 311, 313, 315, 316, 317, 320, 328, 332, 333, 336, 338, 339, 340, 341, 342, 350, F 99, 122, 123, 124, 125, 127, 128, 129, 137, 138, 140, 141, 142, 164, 165, 168, 169, 174, 183, 184, 185, 190, 191, 194, 197, 198, 211, 213, 249, 250, 252, 267, 271, 274, 275, 276, 277, 285, 286, 287, 290, 291, 294, 295, 298, 301, 302, 305, 307, 308, 309, 310, 311, 313, 315, 316, 317, 320, 330, 331, 332, 333, 335, 336, 337, 338, 339, 340, 341, 342, Non-swapped-domain interface residues and interactions: Chains Residues A 55, 95, 99, 101, 120, 122, 123, 124, 125, 127, 128, 137, 138, 140, 141, 142, 143, 164, 165, 168, 169, 174, 185, 190, 191, 194, 197, 198, 211, 213, 249, 250, 252, 267, 271, 274, 275, 276, 277, 290, 294, 295, 298, 305, 307, 308, 309, 310, 311, 313, 315, 316, 317, 320, 330, 331, 332, 333, 335, 336, 337, 338, 339, 340, 341, 342, 353, B 55, 95, 99, 101, 122, 123, 124, 125, 126, 127, 128, 137, 138, 140, 141, 142, 144, 151, 164, 168, 169, 175, 183, 184, 185, 189, 190, 191, 193, 197, 198, 210, 211, 212, 213, 215, 228, 249, 250, 252, 262, 267, 271, 274, 275, 276, 277, 285, 286, 287, 290, 291, 294, 295, 298, 301, 302, 304, 305, 307, 308, 309, 310, 311, 313, 315, 316, 317, 320, 328, 332, 333, 336, 338, 339, 340, 341, 342, 350, C 39, 95, 101, 123, 126, 139, 145, 164, 168, 169, 173, 174, 175, 183, 184, 185, 189, 190, 191, 193, 197, 198, 210, 211, 212, 213, 215, 217, 228, 250, 252, 254, 260, 262, 267, 271, 277, 285, 286, 287, 290, 291, 294, 295, 298, 301, 302, 307, 310, 311, 313, 315, 316, 317, 320, 330, 332, 333, 334, 336, 338, 339, 340, 341, 342, 356, D 39, 54, 55, 95, 101, 123, 126, 127, 128, 129, 130, 132, 133, 137, 138, 139, 140, 141, 143, 144, 145, 354, 356, E 55, 95, 101, 130, 132, 133, 144, F 55, 95, 101, 120, 130, 132, 133, 143,

Swapped domains are represented using trasperent spheres. Non-swapped part is represented using light color and cartoon representation. Hinge region is shown in yellow color.

Mutations in critical regions:

Chains	Hinge	Domain swapped interface	Non-swapped interface	Swapped Domain
F	No mutation	No mutation	No mutation	No mutation
A	No mutation	No mutation	No mutation	No mutation
D	No mutation	No mutation	No mutation	No mutation
C	No mutation	No mutation	No mutation	No mutation
E	No mutation	No mutation	No mutation	No mutation
B	No mutation	No mutation	No mutation	No mutation
C	No mutation	No mutation	No mutation	No mutation
B	No mutation	No mutation	No mutation	No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:2GZA

B:2GZA

C:2GZA

D:2GZA

E:2GZA

F:2GZA

JOY Structural annotation for hinge hinge and swapped domain:

Hinge	Swapped domain

JOY output:

ali file:	2GZA.ali
atm file:	2GZA.atm
cof file:	2GZA.cof
hbd file:	2GZA.hbd
html file:	2GZA.html
pdb file:	2GZA.pdb
ps file:	2GZA.ps
psa file:	2GZA.psa
rtf file:	2GZA.rtf
sst file:	2GZA.sst
tem file:	2GZA.tem