3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 2GYS

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF00041 Fibronectin type III domain PF00041 PF00041

Conserved Domain Database Superfamily Annotations: 2GYS

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 2GYS 206813 cl00065 FN3 superfamily - -

2 2GYS 206813 cl00065 FN3 superfamily - -

3 2GYS 209467 cl12153 IL6Ra-bind superfamily - -

Structural Details of PDB entry 2GYS

Structural Details of PDB entry 2GYS

PDBid Chains Hinge Swapped Domain

2GYS A,B A:91-93,B:91-93;A:306-310,B:306-310 A:94-305,B:94-305

Swapped-domain interface residues and interactions:

Chains Residues
A 3, 4, 5, 28, 29, 32, 33, 91, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 106, 107, 108, 110, 132, 139, 140, 160, 200, 201, 217, 218, 219, 220, 221, 224, 225, 226, 227, 228, 229, 230, 231, 234, 243, 244, 245, 246, 247, 248, 249, 250, 276, 295, 296, 299, 300, 301, 302, 303, 304, 305, 306,

B 2, 3, 4, 5, 28, 29, 32, 33, 95, 96, 97, 98, 99, 100, 101, 102, 103, 106, 107, 108, 110, 132, 139, 140, 159, 189, 200, 201, 217, 218, 219, 220, 221, 224, 225, 226, 227, 228, 229, 230, 231, 234, 241, 243, 244, 245, 246, 247, 248, 249, 250, 276, 295, 296, 299, 300, 301, 302, 303, 304, 305, 306,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 1, 2, 6, 9, 10, 11, 12, 13, 14, 15, 16, 35, 40, 43, 59, 78, 79, 80, 81, 83, 84, 85, 86, 87, 88, 93, 307, 309, 310, 311, 312, 313, 314, 315, 316, 317, 319, 320, 321, 323, 403, 406, 418,

B 1, 6, 9, 11, 12, 13, 14, 15, 35, 40, 43, 59, 81, 83, 84, 85, 86, 87, 88, 91, 93, 307, 309, 310, 311, 312, 313, 314, 315, 316, 317, 319, 320, 321, 323, 344, 345, 346, 348, 402, 403, 406, 409,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:2GYS B:2GYS

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 2GYS.ali
atm file: 2GYS.atm
cof file: 2GYS.cof
hbd file: 2GYS.hbd
html file: 2GYS.html
pdb file: 2GYS.pdb
ps file: 2GYS.ps
psa file: 2GYS.psa
rtf file: 2GYS.rtf
sst file: 2GYS.sst
tem file: 2GYS.tem