3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 2GIC

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF00945 Rhabdovirus nucleocapsid protein PF00945 PF00945

Gene Ontology Annotations: 2GIC

No. GO ID GO Description Linkout - AmiGO

1 GO:0019013 viral nucleocapsid GO:0019013

Conserved Domain Database Superfamily Annotations: 2GIC

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 2GIC 201520 cl03029 Rhabdo_ncap superfamily - -

Structural Details of PDB entry 2GIC

Structural Details of PDB entry 2GIC

PDBid Chains Hinge Swapped Domain

2GIC A,D,C,E,B A:18-29,D:18-29,C:18-29,E:18-29,B:18-29;A:341-352,D:341-352,C:341-352,E:341-352,B:341-352 A:30-340,D:30-340,C:30-340,E:30-340,B:30-340

Swapped-domain interface residues and interactions:

Chains Residues
A 5, 14, 15, 16, 17, 18, 19, 20, 62, 66, 143, 146, 149, 151, 154, 155, 157, 158, 160, 161, 164, 165, 166, 168, 178, 179, 180, 184, 187, 188, 206, 207, 211, 214, 215, 218, 219, 222, 224, 226, 228, 231, 232, 233, 235, 236, 237, 239, 242, 243, 244, 246, 247, 249, 250, 251, 252, 255, 256, 258, 259, 262, 264, 268, 269, 271, 279, 285, 286, 290, 291, 292, 308, 309, 311, 312, 314, 315, 317, 318, 320, 321, 322, 323, 324, 325, 326, 329, 330, 338, 339, 340, 342, 343, 344, 345, 346, 347, 348, 349,

B 2, 5, 14, 15, 16, 17, 18, 19, 20, 63, 143, 146, 149, 151, 155, 161, 164, 165, 166, 168, 178, 179, 180, 184, 187, 188, 206, 207, 214, 215, 218, 219, 222, 224, 226, 228, 231, 232, 233, 235, 236, 237, 239, 242, 243, 244, 246, 247, 249, 250, 251, 252, 255, 256, 258, 259, 262, 264, 268, 269, 271, 279, 285, 286, 287, 290, 291, 292, 308, 309, 311, 312, 315, 317, 318, 320, 321, 322, 323, 324, 325, 326, 329, 330, 338, 339, 340, 342, 343, 344, 345, 346, 347, 348, 349, 388,

C 2, 5, 14, 15, 16, 17, 18, 19, 20, 62, 64, 66, 143, 146, 149, 151, 155, 158, 160, 161, 164, 165, 166, 168, 170, 178, 179, 180, 184, 187, 206, 207, 214, 215, 218, 219, 222, 224, 226, 228, 231, 232, 233, 235, 236, 237, 239, 242, 243, 244, 246, 247, 249, 250, 251, 252, 255, 256, 258, 259, 262, 264, 268, 269, 271, 279, 285, 286, 290, 291, 292, 308, 309, 311, 312, 315, 317, 318, 319, 320, 321, 322, 323, 324, 325, 326, 329, 330, 338, 339, 340, 342, 343, 344, 345, 346, 347, 348, 349,

D 63, 66, 86, 143, 146, 149, 150, 151, 154, 155, 158, 161, 162, 164, 165, 166, 168, 178, 179, 180, 184, 187, 188, 206, 207, 211, 214, 215, 218, 219, 222, 224, 226, 228, 229, 231, 232, 233, 235, 236, 237, 239, 242, 243, 244, 246, 247, 249, 250, 251, 252, 253, 255, 256, 258, 259, 262, 264, 268, 269, 271, 279, 285, 286, 291, 292, 308, 309, 311, 312, 315, 317, 318, 319, 320, 321, 322, 323, 324, 325, 326, 329, 330, 338, 339, 340, 342, 343, 344, 345, 346, 347, 348, 349,

E 2, 5, 14, 16, 17, 18, 19, 20, 63, 143, 146, 149, 151, 154, 155, 157, 158, 160, 161, 164, 165, 166, 167, 168, 178, 179, 180, 183, 184, 187, 206, 207, 211, 214, 215, 218, 219, 222, 224, 226, 228, 231, 232, 233, 235, 236, 237, 239, 242, 243, 246, 247, 249, 250, 251, 252, 255, 256, 258, 259, 262, 264, 268, 269, 271, 279, 285, 286, 290, 291, 292, 308, 309, 311, 312, 314, 315, 317, 318, 319, 320, 321, 322, 323, 324, 325, 326, 329, 330, 338, 339, 340,

F 2, 5, 14, 15, 16, 17, 18, 19, 20, 179, 180, 184, 321, 322, 323, 324, 325, 388,

G 161, 166, 233, 236, 237, 239, 308, 309, 339, 342, 343, 344, 345, 346, 347, 348, 349,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 2, 3, 4, 6, 7, 8, 21, 22, 23, 26, 341, 350, 351, 352, 353, 354, 356, 362, 364, 369, 371, 374, 375, 376, 379, 380, 382, 383, 387, 388, 399, 402, 403, 405, 408, 410, 415, 418, 419, 422,

B 4, 6, 7, 8, 9, 22, 23, 26, 341, 350, 351, 352, 353, 354, 356, 358, 369, 371, 373, 376, 379, 380, 382, 383, 387, 399, 402, 403, 408, 410, 414, 415, 418, 419, 422,

C 4, 6, 7, 8, 9, 21, 22, 23, 26, 341, 350, 351, 352, 353, 354, 356, 374, 375, 376, 379, 380, 382, 383, 386, 387, 388, 399, 402, 403, 405, 408, 410, 414, 415, 418, 419, 422,

D 2, 4, 5, 6, 7, 8, 14, 15, 16, 17, 18, 19, 20, 22, 23, 26, 350, 351, 352, 353, 354, 355, 356, 358, 364, 371, 375, 376, 379, 380, 383, 386, 387, 388, 394, 399, 402, 403, 405, 408, 409, 410, 414, 415, 418, 419, 422,

E 3, 4, 6, 7, 8, 22, 23, 26, 342, 343, 344, 345, 346, 347, 348, 349, 350, 351, 352, 353, 354, 356, 360, 363, 364, 369, 374, 376, 379, 380, 382, 383, 386, 387, 388, 394, 399, 402, 403, 405, 408, 409, 410, 414, 415, 418, 419, 422,

F 4, 6, 7, 8, 22, 23, 26, 63, 66, 86, 143, 146, 149, 150, 151, 154, 155, 158, 161, 162, 164, 165, 166, 168, 178, 187, 188, 206, 207, 211, 214, 215, 218, 219, 222, 224, 226, 228, 229, 231, 232, 233, 235, 236, 237, 239, 242, 243, 244, 246, 247, 249, 250, 251, 252, 253, 255, 256, 258, 259, 262, 264, 268, 269, 271, 279, 285, 286, 291, 292, 308, 309, 311, 312, 315, 317, 318, 319, 320, 326, 329, 330, 338, 339, 340, 342, 343, 344, 345, 346, 347, 348, 349, 350, 351, 352, 353, 354, 355, 356, 358, 364, 371, 375, 376, 379, 380, 383, 386, 387, 394, 399, 402, 403, 405, 408, 409, 410, 414, 415, 418, 419, 422,

G 2, 3, 4, 5, 6, 7, 8, 14, 16, 17, 18, 19, 20, 22, 23, 26, 63, 143, 146, 149, 151, 154, 155, 157, 158, 160, 164, 165, 167, 168, 178, 179, 180, 183, 184, 187, 206, 207, 211, 214, 215, 218, 219, 222, 224, 226, 228, 231, 232, 235, 242, 243, 246, 247, 249, 250, 251, 252, 255, 256, 258, 259, 262, 264, 268, 269, 271, 279, 285, 286, 290, 291, 292, 311, 312, 314, 315, 317, 318, 319, 320, 321, 322, 323, 324, 325, 326, 329, 330, 338, 340, 350, 351, 352, 353, 354, 356, 360, 363, 364, 369, 374, 376, 379, 380, 382, 383, 386, 387, 388, 394, 399, 402, 403, 405, 408, 409, 410, 414, 415, 418, 419, 422,

H 2, 4, 5, 6, 7, 8, 9, 14, 15, 16, 17, 18, 19, 20, 22, 23, 26, 63, 143, 146, 149, 151, 155, 161, 164, 165, 166, 168, 178, 179, 180, 184, 187, 188, 206, 207, 214, 215, 218, 219, 222, 224, 226, 228, 231, 232, 233, 235, 236, 237, 239, 242, 243, 244, 246, 247, 249, 250, 251, 252, 255, 256, 258, 259, 262, 264, 268, 269, 271, 279, 285, 286, 287, 290, 291, 292, 308, 309, 311, 312, 315, 317, 318, 320, 321, 322, 323, 324, 325, 326, 329, 330, 338, 339, 340, 341, 342, 343, 344, 345, 346, 347, 348, 349, 350, 351, 352, 353, 354, 356, 358, 369, 371, 373, 376, 379, 380, 382, 383, 387, 388, 399, 402, 403, 408, 410, 414, 415, 418, 419, 422,

I 2, 4, 5, 6, 7, 8, 9, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 26, 62, 64, 66, 143, 146, 149, 151, 155, 158, 160, 161, 164, 165, 166, 168, 170, 178, 179, 180, 184, 187, 206, 207, 214, 215, 218, 219, 222, 224, 226, 228, 231, 232, 233, 235, 236, 237, 239, 242, 243, 244, 246, 247, 249, 250, 251, 252, 255, 256, 258, 259, 262, 264, 268, 269, 271, 279, 285, 286, 290, 291, 292, 308, 309, 311, 312, 315, 317, 318, 319, 320, 321, 322, 323, 324, 325, 326, 329, 330, 338, 339, 340, 341, 342, 343, 344, 345, 346, 347, 348, 349, 350, 351, 352, 353, 354, 356, 374, 375, 376, 379, 380, 382, 383, 386, 387, 388, 399, 402, 403, 405, 408, 410, 414, 415, 418, 419, 422,

J 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45,

K 2, 3, 4, 5, 6, 7, 8, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 26, 62, 66, 143, 146, 149, 151, 154, 155, 157, 158, 160, 161, 164, 165, 166, 168, 178, 179, 180, 184, 187, 188, 206, 207, 211, 214, 215, 218, 219, 222, 224, 226, 228, 231, 232, 233, 235, 236, 237, 239, 242, 243, 244, 246, 247, 249, 250, 251, 252, 255, 256, 258, 259, 262, 264, 268, 269, 271, 279, 285, 286, 290, 291, 292, 308, 309, 311, 312, 314, 315, 317, 318, 320, 321, 322, 323, 324, 325, 326, 329, 330, 338, 339, 340, 341, 342, 343, 344, 345, 346, 347, 348, 349, 350, 351, 352, 353, 354, 356, 362, 364, 369, 371, 374, 375, 376, 379, 380, 382, 383, 387, 388, 399, 402, 403, 405, 408, 410, 415, 418, 419,

R 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45,

Swapped domains are represented using trasperent spheres.
Non-swapped part is reprented using light color and cartoon reprentation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

D No mutation No mutation No mutation No mutation

C No mutation No mutation No mutation No mutation

E No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

D No mutation No mutation No mutation No mutation

C No mutation No mutation No mutation No mutation

E No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

3:2GIC A:2GIC K:2GIC

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 2GIC.ali
atm file: 2GIC.atm
pdb file: 2GIC.pdb
psa file: 2GIC.psa
sst file: 2GIC.sst