3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 2GED

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF09439 Signal recognition particle receptor beta subunit PF09439 PF09439

2 A PF00025 ADP-ribosylation factor family PF00025 PF00025

3 A PF01926 50S ribosome-binding GTPase PF01926 PF01926

Gene Ontology Annotations: 2GED

No. GO ID GO Description Linkout - AmiGO

1 GO:0005525 GTP binding GO:0005525

Conserved Domain Database Superfamily Annotations: 2GED

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 2GED 206691 SR_beta C cl09099

2 2GED 212613 cl09099 P-loop_NTPase superfamily C -

3 2GED 212613 cl09099 P-loop_NTPase superfamily N -

Structural Details of PDB entry 2GED

Structural Details of PDB entry 2GED

PDBid Chains Hinge Swapped Domain

2GED A,B A:94-97,B:94-97 A:77-93,B:77-93

Swapped-domain interface residues and interactions:

Chains Residues
A 40, 41, 42, 43, 44, 45, 46, 47, 52, 78, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 91, 92, 93,

B 40, 41, 42, 43, 44, 45, 46, 47, 52, 78, 80, 82, 83, 84, 85, 86, 87, 88, 89, 91, 92, 93,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 39, 51, 55, 58, 59, 94, 95, 96, 98, 101, 105, 131, 134, 135, 138, 182, 244,

B 39, 51, 55, 58, 59, 94, 95, 96, 98, 101, 105, 131, 134, 135, 138, 244,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:2GED B:2GED

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 2GED.ali
atm file: 2GED.atm
cof file: 2GED.cof
hbd file: 2GED.hbd
html file: 2GED.html
pdb file: 2GED.pdb
ps file: 2GED.ps
psa file: 2GED.psa
rtf file: 2GED.rtf
sst file: 2GED.sst
tem file: 2GED.tem