3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 2FL4

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF13302 Acetyltransferase (GNAT) domain PF13302 PF13302

2 A PF13673 Acetyltransferase (GNAT) domain PF13673 PF13673

3 A PF13420 Acetyltransferase (GNAT) domain PF13420 PF13420

4 A PF13508 Acetyltransferase (GNAT) domain PF13508 PF13508

5 A PF13523 Acetyltransferase (GNAT) domain PF13523 PF13523

6 A PF00583 Acetyltransferase (GNAT) family PF00583 PF00583

7 A PF08445 FR47-like protein PF08445 PF08445

Conserved Domain Database Superfamily Annotations: 2FL4

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 2FL4 173926 NAT_SF C cl00357

2 2FL4 212199 NAT_SF superfamily C -

3 2FL4 212199 NAT_SF superfamily C -

Structural Details of PDB entry 2FL4

Structural Details of PDB entry 2FL4

PDBid Chains Hinge Swapped Domain

2FL4 A,B A:42-44,B:42-44 A:0-41,B:0-41

Swapped-domain interface residues and interactions:

Chains Residues
A 1, 2, 3, 4, 5, 6, 7, 8, 12, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 40, 41, 47, 48, 49, 50, 51, 52, 53, 58, 59, 73, 74, 78, 79, 90, 112, 115, 135, 136,

B 1, 2, 3, 4, 5, 6, 7, 8, 12, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 40, 41, 47, 48, 49, 50, 51, 52, 53, 58, 59, 73, 74, 78, 79, 90, 112, 115, 135, 136,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 42, 44, 45, 46, 56, 65, 66, 76, 77, 80, 82, 85, 86, 89, 93, 94, 97, 114, 134, 138, 146,

B 42, 44, 45, 46, 56, 65, 66, 76, 77, 80, 82, 85, 86, 89, 93, 94, 97, 114, 134, 138,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:2FL4 B:2FL4

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 2FL4.ali
atm file: 2FL4.atm
cof file: 2FL4.cof
hbd file: 2FL4.hbd
html file: 2FL4.html
pdb file: 2FL4.pdb
ps file: 2FL4.ps
psa file: 2FL4.psa
rtf file: 2FL4.rtf
sst file: 2FL4.sst
tem file: 2FL4.tem