3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 2FJG

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 V PF00341 Platelet-derived growth factor (PDGF) PF00341 PF00341

2 A PF13895 Immunoglobulin domain PF13895 PF13895

3 A PF13895 Immunoglobulin domain PF13895 PF13895

4 A PF13927 Immunoglobulin domain PF13927 PF13927

5 A PF13927 Immunoglobulin domain PF13927 PF13927

6 A PF00047 Immunoglobulin domain PF00047 PF00047

Conserved Domain Database Superfamily Annotations: 2FJG

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 2FJG 143182 cd04981 IgV_H - cl11960

2 2FJG 212623 cl11960 Ig superfamily - -

3 2FJG 143186 cd04985 IgC_CH1 - cl11960

4 2FJG 212623 cl11960 Ig superfamily - -

5 2FJG 212623 cl11960 Ig superfamily - -

Structural Details of PDB entry 2FJG

Structural Details of PDB entry 2FJG

PDBid Chains Hinge Swapped Domain

2FJG A,B A:91-97,B:100-107 A:1-90,B:1-99

Swapped-domain interface residues and interactions:

Chains Residues
A 32, 34, 36, 38, 41, 43, 44, 46, 49, 50, 55, 87, 89, 92, 94, 96, 98,

B 39, 44, 45, 47, 52, 53, 54, 59, 95, 103, 104, 105, 106, 107, 108, 110, 111, 112,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 91, 95, 116, 117, 118, 119, 121, 122, 123, 124, 129, 131, 133, 135, 137, 138, 160, 161, 162, 163, 164, 165, 167, 174, 176, 178, 180, 211,

B 129, 130, 131, 132, 134, 142, 143, 144, 148, 150, 171, 173, 174, 176, 178, 186, 188, 190, 216, 221,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:2FJG B:2FJG

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 2FJG.ali
atm file: 2FJG.atm
cof file: 2FJG.cof
hbd file: 2FJG.hbd
html file: 2FJG.html
pdb file: 2FJG.pdb
ps file: 2FJG.ps
psa file: 2FJG.psa
rtf file: 2FJG.rtf
sst file: 2FJG.sst
tem file: 2FJG.tem