Pfam Domains mapped on to the structure: 2FGW

No.	Chain ID	Pfam ID	Pfam Description	Linkout - Pfam	Linkout - CDD
1	L	PF13895	Immunoglobulin domain	PF13895	PF13895
2	L	PF13895	Immunoglobulin domain	PF13895	PF13895
3	L	PF13927	Immunoglobulin domain	PF13927	PF13927
4	L	PF13927	Immunoglobulin domain	PF13927	PF13927
5	L	PF00047	Immunoglobulin domain	PF00047	PF00047

Conserved Domain Database Superfamily Annotations: 2FGW

No.	PDB ID	PSSM ID	CDD Accession	Superfamily Short Name	Linkout - CDD
1	2FGW	143182	cd04981	IgV_H -	cl11960
2	2FGW	212623	cl11960	Ig	superfamily - -
3	2FGW	143186	cd04985	IgC_CH1 -	cl11960
4	2FGW	212623	cl11960	Ig	superfamily - -
5	2FGW	212623	cl11960	Ig	superfamily - -

Structural Details of PDB entry 2FGW PDBid Chains Hinge Swapped Domain 2FGW H,L H:42-45,L:41-44 H:1-41,L:1-40 Swapped-domain interface residues and interactions: Chains Residues H 39, 110, L 32, 34, 36, 38, Non-swapped-domain interface residues and interactions: Chains Residues H 43, 44, 45, 47, 59, 62, 95, 100, 109, 111, 112, 114, 115, 133, 134, 135, 136, 138, 142, 143, 146, 148, 152, 154, 175, 177, 178, 180, 182, 183, 190, 192, 194, 220, 225, 226, 227, L 42, 43, 44, 46, 49, 55, 87, 89, 91, 94, 95, 96, 98, 99, 100, 116, 117, 118, 119, 121, 122, 123, 124, 127, 129, 131, 133, 135, 137, 138, 160, 162, 163, 164, 174, 176, 178, 207, 211, 213, 214,

Swapped domains are represented using trasperent spheres. Non-swapped part is represented using light color and cartoon representation. Hinge region is shown in yellow color.

Mutations in critical regions:

Chains	Hinge	Domain swapped interface	Non-swapped interface	Swapped Domain
H	No mutation	No mutation	No mutation	No mutation
L	No mutation	No mutation	HIS(55)GLN, GLY(91)SER, LEU(94)THR, PRO(96)TYR,	SER(14)PHE, ASP(28)SER, ASN(30)SER, ASN(31)SER,

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

H:2FGW

JOY Structural annotation for hinge hinge and swapped domain:

Hinge	Swapped domain

JOY output:

ali file:	2FGW.ali
atm file:	2FGW.atm
cof file:	2FGW.cof
hbd file:	2FGW.hbd
html file:	2FGW.html
pdb file:	2FGW.pdb
ps file:	2FGW.ps
psa file:	2FGW.psa
rtf file:	2FGW.rtf
sst file:	2FGW.sst
tem file:	2FGW.tem