3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 2F7S

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF00025 ADP-ribosylation factor family PF00025 PF00025

2 A PF00071 Ras family PF00071 PF00071

3 A PF08477 Miro-like protein PF08477 PF08477

4 A PF00009 Elongation factor Tu GTP binding domain PF00009 PF00009

Gene Ontology Annotations: 2F7S

No. GO ID GO Description Linkout - AmiGO

1 GO:0005622 intracellular GO:0005622

Conserved Domain Database Superfamily Annotations: 2F7S

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 2F7S 206700 cd04127 Rab27A - cl09099

2 2F7S 212613 cl09099 P-loop_NTPase superfamily - -

Structural Details of PDB entry 2F7S

Structural Details of PDB entry 2F7S

PDBid Chains Hinge Swapped Domain

2F7S A,B A:34-42,B:34-42 A:5-33,B:6-33

Swapped-domain interface residues and interactions:

Chains Residues
A 5, 6, 7, 8, 9, 10, 11, 12, 14, 17, 18, 22, 23, 26, 27, 29, 30, 32, 47, 48, 49, 66, 67, 68, 69, 70, 71, 72, 73, 74, 79,

B 6, 7, 8, 9, 10, 11, 12, 14, 18, 22, 23, 26, 27, 29, 30, 32, 48, 49, 66, 67, 68, 69, 70, 71, 72, 73, 74, 78, 79,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 50, 51, 53, 55, 75, 76, 78, 81, 84, 87, 88, 178, 179, 182, 186, 190,

B 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 50, 51, 53, 55, 75, 76, 81, 82, 84, 87, 88, 174, 175, 178, 179, 182, 186,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:2F7S B:2F7S

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 2F7S.ali
atm file: 2F7S.atm
cof file: 2F7S.cof
hbd file: 2F7S.hbd
html file: 2F7S.html
pdb file: 2F7S.pdb
ps file: 2F7S.ps
psa file: 2F7S.psa
rtf file: 2F7S.rtf
sst file: 2F7S.sst
tem file: 2F7S.tem