3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 2ES0

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF00615 Regulator of G protein signaling domain PF00615 PF00615

Conserved Domain Database Superfamily Annotations: 2ES0

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 2ES0 188660 cd08705 RGS_R7-like - cl02565

2 2ES0 207646 cl02565 RGS superfamily - -

Structural Details of PDB entry 2ES0

Structural Details of PDB entry 2ES0

PDBid Chains Hinge Swapped Domain

2ES0 A,B A:414-419,B:414-419 A:420-452,B:420-452

Swapped-domain interface residues and interactions:

Chains Residues
A 327, 330, 334, 337, 350, 353, 362, 366, 369, 373, 402, 406, 410, 413, 414, 420, 421, 422, 424, 425, 426, 428, 429, 430, 432, 433, 434, 437, 438, 440, 441, 442, 444, 446, 447, 450, 451, 452,

B 327, 330, 334, 337, 350, 353, 362, 366, 369, 373, 402, 406, 410, 413, 414, 420, 421, 422, 424, 425, 426, 428, 429, 430, 432, 433, 434, 437, 438, 440, 441, 442, 444, 446, 447, 450, 451,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 324, 331, 333, 336, 338, 340, 341, 349, 354, 357, 359, 365, 372, 375, 377, 380, 381, 384, 385, 387, 401, 403, 409, 417, 418, 419,

B 324, 331, 333, 336, 338, 340, 341, 349, 354, 357, 359, 365, 372, 375, 377, 380, 381, 384, 385, 387, 401, 403, 409, 417, 418, 419,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

B:2ES0 A:2ES0

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 2ES0.ali
atm file: 2ES0.atm
cof file: 2ES0.cof
hbd file: 2ES0.hbd
html file: 2ES0.html
pdb file: 2ES0.pdb
ps file: 2ES0.ps
psa file: 2ES0.psa
rtf file: 2ES0.rtf
sst file: 2ES0.sst
tem file: 2ES0.tem