Pfam Domains mapped on to the structure: 2E0C

No.	Chain ID	Pfam ID	Pfam Description	Linkout - Pfam	Linkout - CDD
1	A	PF00180	Isocitrate/isopropylmalate dehydrogenase	PF00180	PF00180

Conserved Domain Database Superfamily Annotations: 2E0C

No.	PDB ID	PSSM ID	CDD Accession	Superfamily Short Name	Linkout - CDD
1	2E0C	212218	cl00445	Iso_dh	superfamily - -
2	2E0C	212218	cl00445	Iso_dh	superfamily - -

Structural Details of PDB entry 2E0C PDBid Chains Hinge Swapped Domain 2E0C A,B A:186-187,B:186-187 A:1-185,B:1-185 Swapped-domain interface residues and interactions: Chains Residues A 135, 136, 137, 138, 155, 156, 157, 158, 159, 160, 161, 162, 163, 167, 170, 171, 174, 175, 178, 179, 181, 183, 184, 226, 229, 281, 282, B 135, 136, 137, 138, 155, 156, 157, 158, 159, 160, 161, 162, 163, 167, 170, 171, 174, 175, 178, 179, 181, 182, 183, 184, 226, 229, 281, 282, Non-swapped-domain interface residues and interactions: Chains Residues A 186, 187, 188, 189, 190, 191, 192, 193, 194, 195, 196, 197, 223, 227, 230, 237, 273, 274, 277, 278, 295, 296, 298, 299, 302, 303, 306, 309, 311, 409, B 186, 187, 188, 189, 190, 191, 192, 193, 194, 195, 196, 223, 227, 230, 237, 273, 274, 277, 278, 295, 296, 298, 299, 302, 303, 306, 311,

Swapped domains are represented using trasperent spheres. Non-swapped part is represented using light color and cartoon representation. Hinge region is shown in yellow color.

Mutations in critical regions:

Chains	Hinge	Domain swapped interface	Non-swapped interface	Swapped Domain
A	No mutation	No mutation	No mutation	No mutation
B	No mutation	No mutation	No mutation	No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:2E0C

B:2E0C

JOY Structural annotation for hinge hinge and swapped domain:

Hinge	Swapped domain

JOY output:

ali file:	2E0C.ali
atm file:	2E0C.atm
cof file:	2E0C.cof
hbd file:	2E0C.hbd
html file:	2E0C.html
pdb file:	2E0C.pdb
ps file:	2E0C.ps
psa file:	2E0C.psa
rtf file:	2E0C.rtf
sst file:	2E0C.sst
tem file:	2E0C.tem