Pfam Domains mapped on to the structure: 2DXL

No.	Chain ID	Pfam ID	Pfam Description	Linkout - Pfam	Linkout - CDD
1	A	PF12850	Calcineurin-like phosphoesterase superfamily domain	PF12850	PF12850
2	A	PF00149	Calcineurin-like phosphoesterase	PF00149	PF00149

Gene Ontology Annotations: 2DXL

No.	GO ID	GO Description	Linkout - AmiGO
1	GO:0016787	hydrolase activity	GO:0016787

Conserved Domain Database Superfamily Annotations: 2DXL

No.	PDB ID	PSSM ID	CDD Accession	Superfamily Short Name	Linkout - CDD
1	2DXL	163645	cd07402	MPP_GpdQ -	cl13995
2	2DXL	212351	cl13995	MPP_superfamily	superfamily - -
3	2DXL	212351	cl13995	MPP_superfamily	superfamily - -

Structural Details of PDB entry 2DXL PDBid Chains Hinge Swapped Domain 2DXL F,A,D,C,E,B F:254-256,A:255-258,D:254-256,C:254-256,E:254-256,B:255-258 F:257-271,A:259-271,D:257-271,C:257-271,E:257-271,B:259-271 Swapped-domain interface residues and interactions: Chains Residues A 19, 54, 227, 228, 229, 230, 231, 260, 261, 262, 263, 267, 268, 269, 270, 271, B 19, 54, 227, 228, 229, 230, 231, 260, 261, 262, 263, 267, 268, 269, 270, Non-swapped-domain interface residues and interactions: Chains Residues A 12, 21, 40, 53, 56, 81, 160, 161, 162, 163, 189, 190, 198, 199, 200, 201, 202, 203, 204, 205, 206, 208, 221, 222, 223, 224, 232, 233, 234, 241, 243, 246, 248, 249, 250, 251, 253, 255, 257, 258, B 12, 21, 40, 53, 56, 81, 160, 161, 162, 163, 190, 198, 199, 200, 201, 202, 203, 204, 205, 206, 208, 221, 222, 223, 224, 232, 233, 234, 241, 243, 246, 248, 249, 250, 251, 253, 255, 257, 258,

Swapped domains are represented using trasperent spheres. Non-swapped part is represented using light color and cartoon representation. Hinge region is shown in yellow color.

Mutations in critical regions:

Chains	Hinge	Domain swapped interface	Non-swapped interface	Swapped Domain
F	No mutation	No mutation	No mutation	No mutation
A	No mutation	ASP(227)ARG,	No mutation	No mutation
D	No mutation	No mutation	No mutation	No mutation
C	No mutation	No mutation	No mutation	No mutation
E	No mutation	No mutation	No mutation	No mutation
B	No mutation	ASP(227)ARG,	No mutation	No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:2DXL

B:2DXL

C:2DXL

D:2DXL

E:2DXL

F:2DXL

JOY Structural annotation for hinge hinge and swapped domain:

Hinge	Swapped domain

JOY output:

ali file:	2DXL.ali
atm file:	2DXL.atm
cof file:	2DXL.cof
hbd file:	2DXL.hbd
html file:	2DXL.html
pdb file:	2DXL.pdb
ps file:	2DXL.ps
psa file:	2DXL.psa
rtf file:	2DXL.rtf
sst file:	2DXL.sst
tem file:	2DXL.tem