3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 2DT5

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF02629 CoA binding domain PF02629 PF02629

Conserved Domain Database Superfamily Annotations: 2DT5

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 2DT5 203556 cl06152 Put_DNA-bind_N superfamily - -

2 2DT5 212616 cl09931 NADB_Rossmann superfamily - -

3 2DT5 212616 cl09931 NADB_Rossmann superfamily - -

Structural Details of PDB entry 2DT5

Structural Details of PDB entry 2DT5

PDBid Chains Hinge Swapped Domain

2DT5 A,B A:189-191,B:189-191 A:192-211,B:192-211

Swapped-domain interface residues and interactions:

Chains Residues
A 2, 3, 74, 75, 76, 166, 167, 169, 183, 185, 192, 193, 194, 195, 196, 197, 198, 199, 200, 201, 203, 205, 207, 209, 210, 211,

B 5, 7, 8, 51, 75, 76, 166, 167, 169, 183, 185, 192, 193, 194, 195, 196, 197, 198, 199, 200, 201, 202, 205, 206,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 4, 5, 6, 8, 9, 10, 12, 13, 16, 17, 20, 37, 38, 39, 40, 47, 51, 52, 77, 79, 81, 90, 91, 93, 94, 95, 97, 98, 99, 100, 101, 105, 143, 150, 171, 173, 187, 188, 189, 190, 191,

B 1, 2, 3, 4, 6, 9, 12, 16, 39, 41, 47, 48, 52, 74, 77, 79, 81, 90, 91, 93, 94, 95, 97, 98, 99, 100, 101, 105, 143, 171, 173, 187, 188, 189, 190,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:2DT5 B:2DT5

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 2DT5.ali
atm file: 2DT5.atm
cof file: 2DT5.cof
hbd file: 2DT5.hbd
html file: 2DT5.html
pdb file: 2DT5.pdb
ps file: 2DT5.ps
psa file: 2DT5.psa
rtf file: 2DT5.rtf
sst file: 2DT5.sst
tem file: 2DT5.tem