3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 2DSC

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF00293 NUDIX domain PF00293 PF00293

Conserved Domain Database Superfamily Annotations: 2DSC

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 2DSC 72882 cd03424 ADPRase_NUDT5 - cl00447

2 2DSC 212606 cl00447 Nudix_Hydrolase superfamily - -

Structural Details of PDB entry 2DSC

Structural Details of PDB entry 2DSC

PDBid Chains Hinge Swapped Domain

2DSC A,D,C,B A:51-60,D:51-60,C:51-60,B:51-60 A:14-50,D:1-50,C:1-50,B:14-50

Swapped-domain interface residues and interactions:

Chains Residues
A 14, 15, 17, 23, 24, 26, 27, 28, 29, 31, 34, 36, 38, 39, 40, 44, 46, 47, 48, 49, 83, 85, 86, 88,

B 14, 15, 17, 23, 24, 26, 27, 28, 29, 31, 34, 36, 39, 40, 44, 46, 47, 48, 49, 83, 85, 86, 88,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 51, 65, 84, 87, 90, 91, 93, 125, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 143, 145, 165, 167, 175, 183, 186, 192, 193, 194, 195, 196, 198, 199, 200, 202, 203, 204, 205, 206, 207, 208,

B 51, 65, 84, 87, 90, 91, 93, 125, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 143, 145, 164, 165, 167, 175, 183, 186, 192, 193, 194, 195, 196, 198, 199, 200, 202, 203, 204, 205, 206, 207,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

D No mutation No mutation No mutation No mutation

C No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:2DSC B:2DSC C:2DSC D:2DSC

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 2DSC.ali
atm file: 2DSC.atm
cof file: 2DSC.cof
hbd file: 2DSC.hbd
html file: 2DSC.html
pdb file: 2DSC.pdb
ps file: 2DSC.ps
psa file: 2DSC.psa
rtf file: 2DSC.rtf
sst file: 2DSC.sst
tem file: 2DSC.tem