3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 2DBB

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF13412 Winged helix-turn-helix DNA-binding PF13412 PF13412

2 A PF08279 HTH domain PF08279 PF08279

3 A PF01037 AsnC family PF01037 PF01037

Conserved Domain Database Superfamily Annotations: 2DBB

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 2DBB 212173 cl00088 HTH superfamily - -

2 2DBB 189815 cl16958 AsnC_trans_reg superfamily - -

3 2DBB 189815 cl16958 AsnC_trans_reg superfamily - -

Structural Details of PDB entry 2DBB

Structural Details of PDB entry 2DBB

PDBid Chains Hinge Swapped Domain

2DBB A,B A:61-67,B:61-67 A:6-60,B:6-60

Swapped-domain interface residues and interactions:

Chains Residues
A 7, 12, 15, 16, 18, 19, 20, 21, 22, 23, 24, 26, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 64, 65, 150,

B 7, 12, 15, 16, 18, 19, 20, 21, 22, 23, 24, 26, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 64, 150,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 62, 63, 66, 67, 69, 71, 73, 83, 86, 87, 90, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 108, 110, 112, 114, 115, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 151,

B 4, 5, 65, 67, 69, 71, 73, 83, 86, 87, 90, 93, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 108, 110, 112, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:2DBB B:2DBB

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 2DBB.ali
atm file: 2DBB.atm
cof file: 2DBB.cof
hbd file: 2DBB.hbd
html file: 2DBB.html
pdb file: 2DBB.pdb
ps file: 2DBB.ps
psa file: 2DBB.psa
rtf file: 2DBB.rtf
sst file: 2DBB.sst
tem file: 2DBB.tem