Pfam Domains mapped on to the structure: 2D1C

No.	Chain ID	Pfam ID	Pfam Description	Linkout - Pfam	Linkout - CDD
1	A	PF00180	Isocitrate/isopropylmalate dehydrogenase	PF00180	PF00180

Conserved Domain Database Superfamily Annotations: 2D1C

No.	PDB ID	PSSM ID	CDD Accession	Superfamily Short Name	Linkout - CDD
1	2D1C	212218	cl00445	Iso_dh	superfamily - -
2	2D1C	212218	cl00445	Iso_dh	superfamily - -

Structural Details of PDB entry 2D1C PDBid Chains Hinge Swapped Domain 2D1C A,B A:192-211,B:192-211 A:2-191,B:2-191 Swapped-domain interface residues and interactions: Chains Residues A 65, 66, 67, 71, 74, 78, 81, 90, 91, 92, 93, 94, 95, 97, 98, 101, 102, 105, 106, 107, 108, 125, 126, 129, 140, 141, 143, 144, 145, 146, 147, 148, 149, 150, 153, 154, 155, 156, 157, 158, 159, 160, 161, 162, 163, 164, 165, 166, 169, 191, 192, 193, 194, 195, 196, 197, 198, 381, 426, 427, 428, 435, 436, 437, 438, 439, 483, 488, 489, 490, 492, 493, 494, 495, 496, B 65, 66, 67, 71, 74, 78, 81, 90, 91, 92, 93, 94, 95, 97, 98, 101, 102, 105, 106, 107, 108, 125, 126, 129, 140, 141, 143, 144, 145, 146, 147, 148, 149, 150, 153, 154, 155, 156, 157, 158, 159, 160, 161, 162, 163, 164, 165, 166, 169, 191, 192, 193, 194, 195, 196, 197, 198, 381, 426, 427, 428, 435, 436, 437, 438, 439, 483, 488, 489, 490, 493, 494, 495, Non-swapped-domain interface residues and interactions: Chains Residues A 201, 203, 204, 222, 223, 224, 225, 227, 228, 231, 232, 245, 246, 248, 249, 252, 253, 256, 259, 260, 261, 272, 334, 382, 384, 387, 389, 395, 397, 434, 440, 441, 443, 445, 458, 462, 465, 466, 469, 473, 474, 475, 476, 477, 478, 479, 481, 491, B 201, 203, 204, 222, 223, 224, 225, 227, 228, 231, 232, 245, 246, 248, 249, 252, 253, 256, 259, 260, 261, 272, 334, 382, 384, 387, 389, 395, 397, 434, 440, 441, 443, 445, 458, 462, 465, 466, 469, 473, 474, 475, 476, 477, 478, 479, 481, 491, 492,

Swapped domains are represented using trasperent spheres. Non-swapped part is represented using light color and cartoon representation. Hinge region is shown in yellow color.

Mutations in critical regions:

Chains	Hinge	Domain swapped interface	Non-swapped interface	Swapped Domain
A	No mutation	No mutation	No mutation	No mutation
B	No mutation	No mutation	No mutation	No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:2D1C

B:2D1C

JOY Structural annotation for hinge hinge and swapped domain:

Hinge	Swapped domain

JOY output:

ali file:	2D1C.ali
atm file:	2D1C.atm
cof file:	2D1C.cof
hbd file:	2D1C.hbd
html file:	2D1C.html
pdb file:	2D1C.pdb
ps file:	2D1C.ps
psa file:	2D1C.psa
rtf file:	2D1C.rtf
sst file:	2D1C.sst
tem file:	2D1C.tem