3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 2CSC

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF00285 Citrate synthase PF00285 PF00285

Conserved Domain Database Superfamily Annotations: 2CSC

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 2CSC 99858 cd06105 ScCit1-2_like - cl00416

2 2CSC 199305 cl00416 CS_ACL-C_CCL superfamily - -

3 2CSC 199305 cl00416 CS_ACL-C_CCL superfamily - -

Structural Details of PDB entry 2CSC

Structural Details of PDB entry 2CSC

PDBid Chains Hinge Swapped Domain

2CSC A,B A:417-425,B:417-425 A:426-433,B:426-433

Swapped-domain interface residues and interactions:

Chains Residues
A 52, 53, 54, 57, 426, 427, 428, 430, 431, 433,

B 52, 53, 54, 57, 426, 427, 428, 430, 431,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 20, 21, 24, 25, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 58, 123, 126, 127, 130, 131, 132, 134, 135, 139, 142, 143, 146, 147, 149, 150, 158, 161, 163, 164, 239, 241, 242, 243, 246, 247, 250, 251, 254, 255, 256, 260, 264, 267, 268, 270, 271, 272, 273, 280, 311, 312, 313, 314, 321, 322, 417, 418, 419, 420, 421, 422, 423, 424, 425,

B 20, 21, 24, 25, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 58, 123, 126, 127, 130, 131, 132, 134, 135, 139, 142, 143, 146, 147, 149, 150, 158, 161, 163, 164, 239, 241, 242, 243, 246, 247, 250, 251, 254, 255, 256, 260, 264, 267, 268, 270, 271, 272, 273, 280, 311, 312, 313, 314, 321, 322, 417, 418, 419, 420, 421, 422, 423, 424, 425,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:2CSC B:2CSC

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 2CSC.ali
atm file: 2CSC.atm
cof file: 2CSC.cof
hbd file: 2CSC.hbd
html file: 2CSC.html
pdb file: 2CSC.pdb
ps file: 2CSC.ps
psa file: 2CSC.psa
rtf file: 2CSC.rtf
sst file: 2CSC.sst
tem file: 2CSC.tem