Pfam Domains mapped on to the structure: 2CGR

No.	Chain ID	Pfam ID	Pfam Description	Linkout - Pfam	Linkout - CDD
1	H	PF13895	Immunoglobulin domain	PF13895	PF13895

Conserved Domain Database Superfamily Annotations: 2CGR

No.	PDB ID	PSSM ID	CDD Accession	Superfamily Short Name	Linkout - CDD
1	2CGR	143182	cd04981	IgV_H -	cl11960
2	2CGR	212623	cl11960	Ig	superfamily - -
3	2CGR	212623	cl11960	Ig	superfamily - -
4	2CGR	212623	cl11960	Ig	superfamily - -

Structural Details of PDB entry 2CGR PDBid Chains Hinge Swapped Domain 2CGR H,L H:128-134,L:124-130 H:135-214,L:131-219 Swapped-domain interface residues and interactions: Chains Residues H 131, 132, 140, 144, 146, 167, 168, 169, 170, 172, 174, 179, 181, 183, 211, L 132, 136, 138, 140, 142, 143, 165, 166, 167, 168, 169, 179, 181, 183, 185, 214, 218, 219, Non-swapped-domain interface residues and interactions: Chains Residues H 39, 44, 45, 47, 50, 59, 61, 95, 101, 102, 103, 104, 105, 106, 107, 108, 125, 126, 127, 128, 129, 130, 133, L 1, 37, 39, 41, 43, 48, 49, 50, 51, 60, 92, 96, 99, 100, 101, 102, 103, 105, 119, 121, 122, 123, 124, 126, 128, 129,

Swapped domains are represented using trasperent spheres. Non-swapped part is represented using light color and cartoon representation. Hinge region is shown in yellow color.

Mutations in critical regions:

Chains	Hinge	Domain swapped interface	Non-swapped interface	Swapped Domain
H	No mutation	No mutation	GLU(39)GLN, ASN(59)LYS, ARG(61)ASN, SER(101)ALA, SER(102)PRO,	No mutation
L	No mutation	No mutation	HIS(39)TYR, LEU(51)PRO,	No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

H:2CGR

JOY Structural annotation for hinge hinge and swapped domain:

Hinge	Swapped domain

JOY output:

ali file:	2CGR.ali
atm file:	2CGR.atm
cof file:	2CGR.cof
hbd file:	2CGR.hbd
html file:	2CGR.html
pdb file:	2CGR.pdb
ps file:	2CGR.ps
psa file:	2CGR.psa
rtf file:	2CGR.rtf
sst file:	2CGR.sst
tem file:	2CGR.tem