Pfam Domains mapped on to the structure: 2C49

No.	Chain ID	Pfam ID	Pfam Description	Linkout - Pfam	Linkout - CDD
1	A	PF00294	pfkB family carbohydrate kinase	PF00294	PF00294

Conserved Domain Database Superfamily Annotations: 2C49

No.	PDB ID	PSSM ID	CDD Accession	Superfamily Short Name	Linkout - CDD
1	2C49	29364	cd01942	ribokinase_group_A -	cl00192
2	2C49	212177	cl00192	ribokinase_pfkB_like	superfamily - -
3	2C49	212177	cl00192	ribokinase_pfkB_like	superfamily - -

Structural Details of PDB entry 2C49 PDBid Chains Hinge Swapped Domain 2C49 A,B A:16-20,B:16-20;A:39-43,B:39-43 A:21-38,B:21-38 Swapped-domain interface residues and interactions: Chains Residues A 25, 26, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 108, 109, 110, 111, 112, 113, 114, 115, 116, 163, B 25, 26, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 94, 108, 109, 110, 111, 112, 113, 114, 115, 116, Non-swapped-domain interface residues and interactions: Chains Residues A 18, 20, 39, 100, 102, 164, 166, 167, 188, 192, 301, B 20, 67, 95, 100, 102,

Swapped domains are represented using trasperent spheres. Non-swapped part is represented using light color and cartoon representation. Hinge region is shown in yellow color.

Mutations in critical regions:

Chains	Hinge	Domain swapped interface	Non-swapped interface	Swapped Domain
A	No mutation	No mutation	No mutation	No mutation
B	No mutation	No mutation	No mutation	No mutation
B	No mutation	No mutation	No mutation	No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:2C49

B:2C49

JOY Structural annotation for hinge hinge and swapped domain:

Hinge	Swapped domain

JOY output:

ali file:	2C49.ali
atm file:	2C49.atm
cof file:	2C49.cof
hbd file:	2C49.hbd
html file:	2C49.html
pdb file:	2C49.pdb
ps file:	2C49.ps
psa file:	2C49.psa
rtf file:	2C49.rtf
sst file:	2C49.sst
tem file:	2C49.tem