3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 2BOL

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF00011 Hsp20/alpha crystallin family PF00011 PF00011

2 A PF00011 Hsp20/alpha crystallin family PF00011 PF00011

Conserved Domain Database Superfamily Annotations: 2BOL

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 2BOL 107247 cd06526 metazoan_ACD - cl00175

2 2BOL 206879 cl00175 alpha-crystallin-Hsps_p23-like superfamily - -

3 2BOL 107247 cd06526 metazoan_ACD - cl00175

4 2BOL 206879 cl00175 alpha-crystallin-Hsps_p23-like superfamily - -

5 2BOL 206879 cl00175 alpha-crystallin-Hsps_p23-like superfamily - -

Structural Details of PDB entry 2BOL

Structural Details of PDB entry 2BOL

PDBid Chains Hinge Swapped Domain

2BOL A,B A:25-31,B:25-31 A:2-24,B:2-24

Swapped-domain interface residues and interactions:

Chains Residues
A 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 15, 16, 17, 18, 19, 20, 21, 22, 24, 39, 42, 43, 50, 108, 109, 110, 125, 126, 128, 129, 130, 131, 173, 174, 175, 176, 177, 178,

B 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 15, 16, 17, 18, 19, 20, 21, 22, 24, 39, 42, 43, 50, 108, 109, 110, 125, 128, 129, 130, 131, 173, 174, 175, 176, 177, 178, 180,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 25, 26, 27, 29, 30, 31, 32, 33, 35, 36, 38, 40, 46, 49, 53, 54, 105, 106, 107, 115, 117, 171, 180, 182, 184, 193, 248, 314,

B 25, 26, 27, 29, 30, 31, 32, 33, 35, 36, 38, 46, 49, 53, 54, 105, 106, 107, 115, 117, 171, 172, 179, 182, 184, 193, 211, 248,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:2BOL B:2BOL

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 2BOL.ali
atm file: 2BOL.atm
cof file: 2BOL.cof
hbd file: 2BOL.hbd
html file: 2BOL.html
pdb file: 2BOL.pdb
ps file: 2BOL.ps
psa file: 2BOL.psa
rtf file: 2BOL.rtf
sst file: 2BOL.sst
tem file: 2BOL.tem