Pfam Domains mapped on to the structure: 2B48

No.	Chain ID	Pfam ID	Pfam Description	Linkout - Pfam	Linkout - CDD
1	A	PF02180	Bcl-2 homology region 4	PF02180	PF02180

Conserved Domain Database Superfamily Annotations: 2B48

No.	PDB ID	PSSM ID	CDD Accession	Superfamily Short Name	Linkout - CDD
1	2B48	132900	cd06845	Bcl-2_like N	cl02575
2	2B48	207655	cl02575	Bcl-2_like superfamily	N -
3	2B48	154971	cl02540	BH4	superfamily - -

Structural Details of PDB entry 2B48 PDBid Chains Hinge Swapped Domain 2B48 A,B A:157-165,B:157-165 A:166-200,B:166-200 Swapped-domain interface residues and interactions: Chains Residues A 1, 5, 6, 9, 86, 89, 93, 120, 151, 166, 167, 168, 169, 170, 171, 172, 173, 174, 175, 177, 178, 179, 181, 182, 187, 188, 189, 190, 191, 192, 194, 195, 196, 197, 198, 199, 200, B 1, 5, 6, 9, 86, 89, 93, 120, 151, 166, 167, 168, 169, 170, 171, 172, 173, 174, 175, 177, 178, 179, 181, 182, 187, 188, 189, 190, 191, 192, 194, 195, 196, 197, 198, 199, Non-swapped-domain interface residues and interactions: Chains Residues A 2, 8, 13, 17, 21, 22, 23, 24, 82, 85, 90, 92, 96, 114, 117, 118, 123, 124, 127, 128, 131, 135, 136, 137, 138, 140, 141, 143, 144, 147, 150, 154, 155, 158, 159, 162, 163, 165, B 2, 8, 13, 17, 21, 22, 23, 24, 82, 85, 90, 92, 96, 114, 117, 118, 123, 124, 127, 128, 131, 135, 136, 137, 138, 140, 141, 143, 144, 147, 150, 154, 155, 158, 159, 162, 163, 165,

Swapped domains are represented using trasperent spheres. Non-swapped part is represented using light color and cartoon representation. Hinge region is shown in yellow color.

Mutations in critical regions:

Chains	Hinge	Domain swapped interface	Non-swapped interface	Swapped Domain
A	No mutation	No mutation	No mutation	No mutation
B	No mutation	No mutation	No mutation	No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:2B48

B:2B48

JOY Structural annotation for hinge hinge and swapped domain:

Hinge	Swapped domain

JOY output:

ali file:	2B48.ali
atm file:	2B48.atm
cof file:	2B48.cof
hbd file:	2B48.hbd
html file:	2B48.html
pdb file:	2B48.pdb
ps file:	2B48.ps
psa file:	2B48.psa
rtf file:	2B48.rtf
sst file:	2B48.sst
tem file:	2B48.tem