Pfam Domains mapped on to the structure: 2AEF

No.	Chain ID	Pfam ID	Pfam Description	Linkout - Pfam	Linkout - CDD
1	A	PF02254	TrkA-N domain	PF02254	PF02254
2	A	PF02080	TrkA-C domain	PF02080	PF02080

Gene Ontology Annotations: 2AEF

No.	GO ID	GO Description	Linkout - AmiGO
1	GO:0006813	potassium ion transport	GO:0006813

Conserved Domain Database Superfamily Annotations: 2AEF

No.	PDB ID	PSSM ID	CDD Accession	Superfamily Short Name	Linkout - CDD
1	2AEF	212616	cl09931	NADB_Rossmann	superfamily - -
2	2AEF	210084	cl15357	ArsB_NhaD_permease	superfamily - -
3	2AEF	210084	cl15357	ArsB_NhaD_permease	superfamily - -

Structural Details of PDB entry 2AEF PDBid Chains Hinge Swapped Domain 2AEF A,B A:228-232,B:228-232 A:233-261,B:233-261 Swapped-domain interface residues and interactions: Chains Residues A 126, 129, 130, 133, 134, 179, 180, 227, 229, 231, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 297, 302, B 126, 129, 130, 133, 134, 179, 180, 182, 208, 227, 229, 231, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 297, 302, Non-swapped-domain interface residues and interactions: Chains Residues A 118, 125, 182, 206, 208, 210, 212, 213, 214, 230, 232, 262, 264, 266, 286, 290, 292, 294, 299, 300, 304, 305, 317, 319, 321, 339, B 118, 125, 132, 206, 210, 213, 214, 232, 262, 264, 266, 286, 290, 292, 294, 299, 300, 301, 304, 305, 317, 319, 321,

Swapped domains are represented using trasperent spheres. Non-swapped part is represented using light color and cartoon representation. Hinge region is shown in yellow color.

Mutations in critical regions:

Chains	Hinge	Domain swapped interface	Non-swapped interface	Swapped Domain
A	No mutation	No mutation	PRO(339)-,	No mutation
B	No mutation	No mutation	No mutation	No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:2AEF

B:2AEF

JOY Structural annotation for hinge hinge and swapped domain:

Hinge	Swapped domain

JOY output:

ali file:	2AEF.ali
atm file:	2AEF.atm
cof file:	2AEF.cof
hbd file:	2AEF.hbd
html file:	2AEF.html
pdb file:	2AEF.pdb
ps file:	2AEF.ps
psa file:	2AEF.psa
rtf file:	2AEF.rtf
sst file:	2AEF.sst
tem file:	2AEF.tem