Pfam Domains mapped on to the structure: 2A9F

No.	Chain ID	Pfam ID	Pfam Description	Linkout - Pfam	Linkout - CDD
1	A	PF00390	Malic enzyme, N-terminal domain	PF00390	PF00390
2	A	PF03949	Malic enzyme, NAD binding domain	PF03949	PF03949

Gene Ontology Annotations: 2A9F

No.	GO ID	GO Description	Linkout - AmiGO
1	GO:0055114	oxidation-reduction process	GO:0055114

Conserved Domain Database Superfamily Annotations: 2A9F

No.	PDB ID	PSSM ID	CDD Accession	Superfamily Short Name	Linkout - CDD
1	2A9F	133453	cd05311	NAD_bind_2_malic_enz -	cl09931
2	2A9F	212616	cl09931	NADB_Rossmann	superfamily - -
3	2A9F	201200	cl02855	malic	superfamily - -

Structural Details of PDB entry 2A9F PDBid Chains Hinge Swapped Domain 2A9F A,B A:21-29,B:21-29;A:55-66,B:55-66 A:30-54,B:30-54 Swapped-domain interface residues and interactions: Chains Residues A 9, 11, 12, 30, 31, 33, 36, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 51, 52, 83, 87, 90, 91, 94, B 6, 8, 9, 12, 30, 33, 34, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 78, 83, 87, 90, 91, 94, 95, 101, Non-swapped-domain interface residues and interactions: Chains Residues A 7, 14, 15, 16, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 55, 58, 60, 61, 62, 63, 65, 78, 80, 86, 89, 93, 95, 97, 98, 100, 101, 102, 106, 107, 108, 109, 110, 111, 112, 113, 119, 122, 123, 126, 127, 129, 130, 322, 366, 367, 388, B 11, 13, 14, 15, 16, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 55, 58, 60, 61, 62, 63, 65, 80, 84, 86, 89, 93, 97, 98, 100, 102, 106, 107, 108, 109, 110, 111, 112, 113, 114, 119, 122, 123, 126, 127, 129, 130, 313, 318, 322, 366, 367,

Swapped domains are represented using trasperent spheres. Non-swapped part is represented using light color and cartoon representation. Hinge region is shown in yellow color.

Mutations in critical regions:

Chains	Hinge	Domain swapped interface	Non-swapped interface	Swapped Domain
A	No mutation	No mutation	No mutation	No mutation
B	No mutation	No mutation	No mutation	No mutation
B	No mutation	No mutation	No mutation	No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:2A9F

B:2A9F

JOY Structural annotation for hinge hinge and swapped domain:

Hinge	Swapped domain

JOY output:

ali file:	2A9F.ali
atm file:	2A9F.atm
cof file:	2A9F.cof
hbd file:	2A9F.hbd
html file:	2A9F.html
pdb file:	2A9F.pdb
ps file:	2A9F.ps
psa file:	2A9F.psa
rtf file:	2A9F.rtf
sst file:	2A9F.sst
tem file:	2A9F.tem