Pfam Domains mapped on to the structure: 2A72
No.
Chain ID
Pfam ID
Pfam Description
Linkout - Pfam
Linkout - CDD
1
A
PF00615
Regulator of G protein signaling domain
PF00615
PF00615
Gene Ontology Annotations: 2A72
No.
GO ID
GO Description
Linkout - AmiGO
1
GO:0038032
termination of G-protein coupled receptor signaling pathway
GO:0038032
Conserved Domain Database Superfamily Annotations: 2A72
Structural Details of PDB entry 2A72
Structural Details of PDB entry 2A72
PDBid Chains Hinge Swapped Domain
2A72
A,B
A:411-416,B:411-416
A:417-450,B:417-450
Swapped-domain interface residues and interactions:
Chains Residues
A
324 , 327 , 328 , 331 , 334 , 347 , 350 , 359 , 363 , 399 , 403 , 407 , 410 , 411 , 417 , 418 , 419 , 421 , 422 , 423 , 425 , 426 , 427 , 429 , 430 , 431 , 434 , 435 , 437 , 438 , 439 , 441 , 443 , 444 , 447 , 448 , 450 ,
B
328 , 331 , 334 , 347 , 350 , 359 , 363 , 366 , 399 , 403 , 407 , 410 , 411 , 417 , 418 , 419 , 421 , 422 , 423 , 425 , 426 , 427 , 429 , 430 , 431 , 434 , 435 , 437 , 438 , 439 , 441 , 443 , 444 , 447 , 448 , 449 ,
Non-swapped-domain interface residues and interactions:
Chains Residues
A
322 , 330 , 333 , 335 , 337 , 346 , 351 , 354 , 356 , 360 , 362 , 366 , 369 , 370 , 374 , 377 , 381 , 384 , 398 , 400 , 406 , 414 , 415 , 416 ,
B
324 , 327 , 330 , 333 , 335 , 337 , 346 , 351 , 354 , 356 , 360 , 362 , 369 , 370 , 374 , 377 , 381 , 384 , 398 , 400 , 406 , 414 , 415 , 416 ,
Mutations in critical regions:
Chains
Hinge
Domain swapped interface Non-swapped interface Swapped Domain
A No mutation No mutation No mutation No mutation B No mutation No mutation No mutation No mutation
HIDE output:
JMOL Visualization:
2D-plot:
JOY Structural annotation for hinge hinge and swapped domain:
JOY output:
