3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 1ZD4

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF13419 Haloacid dehalogenase-like hydrolase PF13419 PF13419

2 A PF12695 Alpha/beta hydrolase family PF12695 PF12695

3 A PF12697 Alpha/beta hydrolase family PF12697 PF12697

4 A PF00561 alpha/beta hydrolase fold PF00561 PF00561

Conserved Domain Database Superfamily Annotations: 1ZD4

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 1ZD4 119389 HAD_like N cl11391

2 1ZD4 212620 HAD_like superfamily N -

3 1ZD4 211462 Esterase_lipase superfamily NC -

4 1ZD4 211462 Esterase_lipase superfamily NC -

5 1ZD4 211462 Esterase_lipase superfamily NC -

6 1ZD4 211462 Esterase_lipase superfamily NC -

Structural Details of PDB entry 1ZD4

Structural Details of PDB entry 1ZD4

PDBid Chains Hinge Swapped Domain

1ZD4 A,B A:219-234,B:219-234 A:2-218,B:2-218

Swapped-domain interface residues and interactions:

Chains Residues
A 56, 57, 58, 59, 61, 62, 127, 128, 129, 133, 134, 136, 137, 138, 140, 141, 144, 154, 155, 320, 325, 326, 346, 347, 348, 349, 477, 480, 481, 484, 485,

B 56, 57, 58, 59, 61, 62, 127, 128, 129, 133, 134, 136, 137, 138, 140, 141, 144, 154, 155, 320, 325, 326, 346, 347, 348, 349, 477, 480, 481, 484, 485,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 233, 234, 235, 236, 237, 238, 239, 240, 241, 252, 253, 254, 255, 256, 285, 316, 321, 322, 323, 324, 345, 482, 547,

B 233, 234, 235, 236, 237, 238, 239, 240, 241, 252, 253, 254, 255, 256, 285, 316, 321, 322, 323, 324, 345, 482,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:1ZD4 B:1ZD4

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 1ZD4.ali
atm file: 1ZD4.atm
cof file: 1ZD4.cof
hbd file: 1ZD4.hbd
html file: 1ZD4.html
pdb file: 1ZD4.pdb
ps file: 1ZD4.ps
psa file: 1ZD4.psa
rtf file: 1ZD4.rtf
sst file: 1ZD4.sst
tem file: 1ZD4.tem