3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 1XIU

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF00104 Ligand-binding domain of nuclear hormone receptor PF00104 PF00104

Structural Details of PDB entry 1XIU

Structural Details of PDB entry 1XIU

PDBid Chains Hinge Swapped Domain

1XIU F,A,E,B,H,C,D,G F:418-419,A:416-423,E:418-419,B:416-423,H:418-419,C:418-419,D:418-419,G:418-419 F:420-430,A:424-430,E:420-430,B:424-432,H:420-430,C:420-430,D:420-430,G:420-430

Swapped-domain interface residues and interactions:

Chains Residues
A 244, 247, 276, 424, 425, 426, 427, 428, 429, 430,

B 424, 427, 428, 432,

C 247, 276, 421, 422, 423, 424, 425, 426, 427, 428, 429, 430,

D 423, 424, 427, 428,

E 687, 689,

G 687, 689,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 235, 237, 239, 240, 243, 246, 250, 251, 254, 258, 264, 268, 269, 271, 272, 275, 279, 307, 308, 309, 312, 313, 314, 315, 322, 325, 326, 330, 352, 353, 355, 364, 367, 371, 375, 379, 387, 389, 390, 391, 393, 394, 395, 396, 397, 398, 400, 401, 404, 408, 410, 411, 412, 413, 414, 415, 416, 417, 419, 421, 422, 423,

B 251, 254, 258, 268, 271, 272, 275, 322, 325, 326, 330, 352, 353, 355, 358, 364, 367, 368, 371, 375, 379, 387, 389, 390, 391, 393, 394, 395, 396, 397, 398, 400, 401, 404, 408, 411, 412, 415, 416, 423,

C 235, 237, 239, 240, 243, 244, 246, 250, 251, 254, 258, 264, 268, 269, 271, 272, 275, 279, 307, 308, 309, 312, 313, 314, 315, 322, 325, 326, 330, 352, 353, 355, 364, 367, 371, 375, 379, 387, 389, 390, 391, 393, 394, 395, 396, 397, 398, 400, 401, 404, 408, 410, 411, 412, 413, 414, 415, 416, 417, 419,

D 251, 254, 258, 268, 271, 272, 275, 322, 325, 326, 330, 352, 353, 355, 358, 364, 367, 368, 371, 375, 379, 387, 389, 390, 391, 393, 394, 395, 396, 397, 398, 400, 401, 404, 408, 411, 412, 415, 416, 432,

E 690, 691, 693, 694, 695, 697, 698,

F 688, 689, 690, 691, 693, 694, 695, 697,

G 690, 691, 693, 694, 695, 697, 698,

H 688, 689, 690, 691, 693, 694, 695,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

F No mutation No mutation No mutation No mutation

A No mutation No mutation No mutation No mutation

E No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

H No mutation No mutation No mutation No mutation

C No mutation No mutation No mutation No mutation

D No mutation No mutation No mutation No mutation

G No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:1XIU B:1XIU C:1XIU D:1XIU E:1XIU F:1XIU G:1XIU H:1XIU

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 1XIU.ali
atm file: 1XIU.atm
cof file: 1XIU.cof
hbd file: 1XIU.hbd
html file: 1XIU.html
pdb file: 1XIU.pdb
ps file: 1XIU.ps
psa file: 1XIU.psa
rtf file: 1XIU.rtf
sst file: 1XIU.sst
tem file: 1XIU.tem