Pfam Domains mapped on to the structure: 1WEJ

No.	Chain ID	Pfam ID	Pfam Description	Linkout - Pfam	Linkout - CDD
1	L	PF13895	Immunoglobulin domain	PF13895	PF13895
2	L	PF13927	Immunoglobulin domain	PF13927	PF13927
3	L	PF00047	Immunoglobulin domain	PF00047	PF00047
4	H	PF13895	Immunoglobulin domain	PF13895	PF13895
5	F	PF13442	Cytochrome C oxidase, cbb3-type, subunit III	PF13442	PF13442
6	F	PF00034	Cytochrome c	PF00034	PF00034

Conserved Domain Database Superfamily Annotations: 1WEJ

No.	PDB ID	PSSM ID	CDD Accession	Superfamily Short Name	Linkout - CDD
1	1WEJ	212313	cl11414	Cytochrom_C	superfamily - -

Structural Details of PDB entry 1WEJ PDBid Chains Hinge Swapped Domain 1WEJ H,L H:103-108,L:94-99 H:1-102,L:1-93 Swapped-domain interface residues and interactions: Chains Residues H 35, 39, 42, 44, 45, 47, 59, 60, 61, 62, 95, 99, 100, 101, 102, 103, 105, 107, L 1, 32, 36, 38, 40, 43, 44, 46, 49, 50, 56, 87, 89, 91, 94, 95, 96, 97, 98, 100, Non-swapped-domain interface residues and interactions: Chains Residues H 108, 126, 127, 128, 129, 130, 141, 145, 147, 165, 168, 169, 170, 171, 173, 175, 180, 182, 184, 212, 217, 219, L 114, 116, 118, 119, 121, 123, 124, 127, 131, 133, 135, 137, 138, 158, 159, 160, 161, 162, 163, 164, 165, 167, 169, 174, 176, 178, 180, 214,

Swapped domains are represented using trasperent spheres. Non-swapped part is represented using light color and cartoon representation. Hinge region is shown in yellow color.

Mutations in critical regions:

Chains	Hinge	Domain swapped interface	Non-swapped interface	Swapped Domain
H	ASN(103)GLN, PHE(104)GLU, ASP(105)PRO,	ASP(100)GLY, TYR(101)SER, GLY(102)SER, ASN(103)GLN, ASP(105)PRO,	THR(182)SER,	GLN(3)LYS, GLN(5)LEU, GLN(6)GLU, PRO(14)SER, LYS(43)GLN, SER(55)ASN, ASN(57)GLU, THR(58)ILE, ASP(66)GLY, LYS(67)THR, SER(76)THR, ALA(97)ARG, -(98)ARG, ASP(100)GLY, TYR(101)SER, GLY(102)SER,
L	No mutation	GLN(89)HIS,	PHE(118)LEU,	SER(85)THR, GLN(89)HIS,

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

H:1WEJ

JOY Structural annotation for hinge hinge and swapped domain:

Hinge	Swapped domain

JOY output:

ali file:	1WEJ.ali
atm file:	1WEJ.atm
cof file:	1WEJ.cof
hbd file:	1WEJ.hbd
html file:	1WEJ.html
pdb file:	1WEJ.pdb
ps file:	1WEJ.ps
psa file:	1WEJ.psa
rtf file:	1WEJ.rtf
sst file:	1WEJ.sst
tem file:	1WEJ.tem