3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 1VPX

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF00923 Transaldolase PF00923 PF00923

Conserved Domain Database Superfamily Annotations: 1VPX

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 1VPX 188643 cd00956 Transaldolase_FSA - cl09108

2 1VPX 212614 cl09108 TIM_phosphate_binding superfamily - -

Structural Details of PDB entry 1VPX

Structural Details of PDB entry 1VPX

PDBid Chains Hinge Swapped Domain

1VPX F,A,J,E,B,H,C,D,I,G F:194-196,A:194-196,J:194-196,E:194-196,B:194-196,H:194-196,C:194-196,D:194-196,I:194-196,G:194-196 F:197-216,A:197-216,J:197-211,E:197-215,B:197-207,H:197-208,C:197-207,D:197-208,I:197-214,G:197-214

Swapped-domain interface residues and interactions:

Chains Residues
A 86, 108, 110, 197, 198, 200, 201, 202, 205, 206, 208, 209, 211, 212, 215, 216,

B 108, 110, 197, 198, 200, 201, 202, 205, 206, 207,

C 86, 108, 110, 196, 197, 198, 200, 201, 202, 205, 206, 207,

D 29, 30, 33, 86, 108, 110, 197, 198, 200, 201, 202, 205, 206, 208,

E 29, 30, 33, 86, 108, 110, 197, 198, 200, 201, 202, 205, 206, 208, 209, 212, 215,

F 29, 30, 86, 108, 110, 197, 198, 200, 201, 202, 205, 206, 208, 209, 212, 215, 216,

G 108, 110, 197, 198, 200, 201, 202, 205, 206, 208, 209, 212, 214,

H 29, 30, 33, 86, 108, 110, 197, 198, 200, 201, 202, 205, 206, 208,

I 108, 110, 197, 198, 200, 201, 202, 205, 206, 208, 209, 211, 212, 214,

J 29, 30, 33, 86, 108, 110, 196, 197, 198, 200, 201, 202, 205, 206, 209, 211,

K 0, 154, 156,

L 0, 154, 155, 156,

M 0, 154, 156,

N 0, 154, 155, 156,

O 0, 154, 156,

P 0, 154, 155, 156,

Q 0, 154, 156,

R 0, 154, 156,

S 0, 154, 156,

T 0, 154, 155, 156,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 1, 0, 1, 3, 17, 18, 19, 20, 21, 23, 28, 29, 57, 61, 87, 88, 91, 92, 95, 111, 112, 113, 114, 116, 117, 119, 120, 121, 132, 133, 134, 135, 136, 137, 138, 139, 142, 146, 149, 150, 153, 154, 155, 156, 157, 167, 168, 169, 171, 172, 175, 176, 178, 191, 192, 193, 194, 195, 196,

B 1, 0, 1, 3, 17, 18, 19, 20, 21, 23, 28, 57, 58, 59, 61, 74, 75, 78, 85, 86, 87, 88, 91, 92, 95, 99, 100, 102, 107, 111, 112, 113, 114, 116, 117, 120, 121, 132, 133, 134, 135, 136, 137, 138, 139, 142, 146, 149, 150, 153, 154, 156, 167, 168, 169, 171, 172, 175, 176, 178, 191, 192, 193, 194, 195, 196,

C 0, 1, 3, 17, 18, 19, 20, 21, 23, 29, 30, 57, 61, 87, 88, 91, 92, 95, 111, 112, 113, 114, 116, 117, 119, 120, 121, 132, 133, 134, 135, 136, 137, 138, 139, 142, 146, 149, 150, 153, 154, 156, 157, 167, 168, 169, 171, 172, 175, 176, 178, 191, 192, 193, 194, 195,

D 1, 0, 1, 3, 17, 18, 19, 20, 21, 23, 37, 38, 39, 57, 58, 59, 61, 71, 75, 85, 87, 88, 91, 92, 95, 100, 111, 112, 113, 114, 116, 117, 119, 120, 121, 132, 133, 134, 135, 136, 137, 138, 139, 142, 146, 149, 150, 153, 154, 156, 157, 167, 168, 169, 171, 172, 175, 176, 178, 191, 192, 193, 194, 195, 196,

E 0, 1, 3, 17, 18, 19, 20, 21, 23, 36, 37, 38, 39, 48, 51, 57, 58, 59, 61, 78, 79, 85, 87, 88, 91, 92, 95, 99, 111, 112, 113, 114, 116, 117, 119, 120, 121, 132, 133, 134, 135, 136, 137, 138, 139, 142, 146, 149, 150, 153, 154, 155, 156, 157, 167, 168, 169, 171, 172, 175, 176, 178, 191, 192, 193, 194, 195, 196,

F 1, 0, 1, 3, 18, 19, 20, 21, 23, 28, 37, 39, 57, 58, 59, 61, 85, 87, 88, 91, 92, 95, 107, 111, 112, 113, 114, 116, 117, 119, 120, 121, 132, 133, 134, 135, 136, 137, 138, 139, 142, 146, 149, 150, 153, 154, 156, 157, 167, 168, 169, 171, 172, 175, 176, 178, 191, 192, 193, 194, 195, 196,

G 1, 0, 1, 3, 17, 18, 19, 20, 21, 23, 57, 59, 61, 86, 87, 88, 91, 92, 95, 111, 112, 113, 114, 116, 117, 119, 120, 121, 132, 133, 134, 135, 136, 137, 138, 139, 142, 146, 149, 150, 153, 154, 156, 157, 167, 168, 169, 171, 172, 175, 176, 178, 191, 192, 193, 194, 195, 196,

H 0, 1, 3, 17, 18, 19, 20, 21, 23, 32, 39, 57, 58, 59, 61, 85, 87, 88, 91, 92, 95, 111, 112, 113, 114, 116, 117, 119, 120, 121, 132, 133, 134, 135, 136, 137, 138, 139, 142, 146, 149, 150, 153, 154, 155, 156, 167, 168, 169, 171, 172, 175, 176, 178, 191, 192, 193, 194, 195, 196,

I 1, 0, 1, 3, 17, 18, 19, 20, 21, 29, 57, 59, 61, 86, 87, 88, 91, 92, 95, 111, 112, 113, 114, 116, 117, 119, 120, 121, 132, 133, 134, 135, 136, 137, 138, 139, 142, 146, 149, 150, 153, 154, 155, 156, 157, 167, 168, 169, 171, 172, 175, 176, 178, 191, 192, 193, 194, 195, 196,

J 1, 0, 1, 3, 17, 18, 19, 20, 21, 23, 28, 32, 36, 37, 39, 57, 59, 61, 85, 87, 88, 91, 92, 95, 111, 112, 113, 114, 116, 117, 119, 120, 121, 132, 133, 134, 135, 136, 137, 138, 139, 142, 146, 149, 150, 153, 154, 156, 157, 167, 168, 169, 172, 175, 176, 178, 191, 192, 193, 194, 195,

K 1, 3, 17, 18, 19, 20, 21, 23, 30, 57, 61, 86, 87, 88, 91, 92, 95, 108, 110, 111, 112, 113, 114, 116, 117, 119, 120, 121, 132, 133, 134, 135, 136, 137, 138, 139, 142, 146, 149, 150, 153, 157, 167, 168, 169, 171, 172, 175, 176, 178, 191, 192, 193, 194, 195, 196, 197, 198, 200, 201, 202, 205, 206, 208, 209, 212, 215,

L 1, 1, 3, 18, 19, 20, 21, 23, 61, 86, 87, 88, 91, 92, 95, 108, 110, 111, 112, 113, 114, 116, 117, 119, 120, 121, 132, 133, 134, 135, 136, 137, 138, 139, 142, 146, 149, 150, 153, 157, 167, 168, 169, 171, 172, 175, 176, 178, 191, 192, 193, 194, 195, 196, 197, 198, 200, 201, 202, 205, 206, 208,

M 1, 3, 18, 19, 20, 21, 23, 61, 71, 74, 75, 78, 86, 87, 88, 91, 92, 95, 108, 110, 111, 112, 113, 114, 116, 117, 120, 121, 132, 133, 134, 135, 136, 137, 138, 139, 142, 146, 149, 150, 153, 167, 168, 169, 171, 172, 175, 176, 178, 191, 192, 193, 194, 195, 196, 197, 198, 200, 201, 202, 204,

N 1, 3, 17, 18, 19, 20, 21, 28, 57, 61, 71, 86, 87, 88, 91, 92, 95, 108, 110, 111, 112, 113, 114, 116, 117, 119, 120, 121, 132, 133, 134, 135, 136, 137, 138, 139, 142, 146, 149, 150, 153, 157, 167, 168, 169, 171, 172, 175, 176, 178, 191, 192, 193, 194, 195, 196, 197, 198, 200, 201, 202, 206,

O 1, 1, 3, 17, 18, 19, 20, 21, 23, 28, 29, 30, 33, 37, 39, 44, 48, 51, 57, 58, 59, 61, 85, 86, 87, 88, 91, 92, 95, 99, 100, 101, 108, 110, 111, 112, 113, 114, 116, 117, 119, 120, 121, 132, 133, 134, 135, 136, 137, 138, 139, 142, 146, 149, 150, 153, 167, 168, 169, 171, 172, 175, 176, 178, 191, 192, 193, 194, 195, 196, 197, 198, 200, 201, 202, 204, 205, 206, 208,

P 1, 1, 3, 15, 18, 19, 20, 21, 23, 29, 30, 33, 39, 57, 58, 59, 61, 86, 87, 88, 91, 92, 95, 107, 108, 110, 111, 112, 113, 114, 116, 117, 119, 120, 121, 132, 133, 134, 135, 136, 137, 138, 139, 142, 146, 149, 150, 153, 157, 167, 168, 169, 171, 172, 175, 176, 178, 191, 192, 193, 194, 195, 196, 197, 198, 200, 201, 202, 206, 207,

Q 1, 1, 3, 17, 18, 19, 20, 21, 23, 28, 39, 57, 59, 61, 86, 87, 88, 91, 92, 95, 108, 110, 111, 112, 113, 114, 116, 117, 120, 121, 132, 133, 134, 135, 136, 137, 138, 139, 142, 146, 149, 150, 153, 167, 168, 169, 171, 172, 175, 176, 178, 191, 192, 193, 194, 195, 196, 197, 198, 200, 201, 202, 205, 206, 208, 209, 212, 214,

R 1, 3, 15, 18, 19, 20, 21, 23, 61, 85, 86, 87, 88, 91, 92, 95, 108, 110, 111, 112, 113, 114, 116, 117, 119, 120, 121, 132, 133, 134, 135, 136, 137, 138, 139, 142, 146, 149, 150, 153, 157, 167, 168, 169, 171, 172, 175, 176, 178, 191, 192, 193, 194, 195, 196, 197, 198, 200, 201, 202, 204, 205, 206, 208, 209, 215,

S 1, 3, 17, 18, 19, 20, 21, 23, 29, 30, 33, 38, 39, 57, 58, 59, 61, 85, 86, 87, 88, 91, 92, 95, 107, 108, 110, 111, 112, 113, 114, 116, 117, 120, 121, 132, 133, 134, 135, 136, 137, 138, 139, 142, 146, 149, 150, 153, 157, 167, 168, 169, 171, 172, 175, 176, 178, 191, 192, 193, 194, 195, 196, 197, 198, 200, 201, 202, 204,

T 1, 3, 17, 18, 19, 20, 21, 23, 61, 86, 87, 88, 91, 92, 95, 108, 110, 111, 112, 113, 114, 116, 117, 119, 120, 121, 132, 133, 134, 135, 136, 137, 138, 139, 142, 146, 149, 150, 153, 157, 167, 168, 169, 172, 175, 176, 178, 191, 192, 193, 194, 195, 196, 197, 198, 200, 201, 202, 205, 206, 208, 209, 211, 212,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

F No mutation No mutation No mutation No mutation

A No mutation No mutation No mutation No mutation

J No mutation No mutation No mutation No mutation

E No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

H No mutation No mutation No mutation No mutation

C No mutation No mutation No mutation No mutation

D No mutation No mutation No mutation No mutation

I No mutation No mutation No mutation No mutation

G No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

F:1VPX T:1VPX

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 1VPX.ali
atm file: 1VPX.atm
pdb file: 1VPX.pdb
psa file: 1VPX.psa
sst file: 1VPX.sst