3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 1VL2

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF00764 Arginosuccinate synthase PF00764 PF00764

Gene Ontology Annotations: 1VL2

No. GO ID GO Description Linkout - AmiGO

1 GO:0006526 arginine biosynthetic process GO:0006526

Conserved Domain Database Superfamily Annotations: 1VL2

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 1VL2 30186 cd01999 Argininosuccinate_Synthase - cl00292

2 1VL2 206963 cl00292 AANH_like superfamily - -

3 1VL2 206963 cl00292 AANH_like superfamily - -

Structural Details of PDB entry 1VL2

Structural Details of PDB entry 1VL2

PDBid Chains Hinge Swapped Domain

1VL2 A,B A:359-383,B:359-383 A:384-409,B:384-409

Swapped-domain interface residues and interactions:

Chains Residues
A 118, 119, 124, 128, 131, 132, 133, 135, 144, 272, 326, 384, 386, 387, 389, 390, 393, 394, 396, 397, 398, 400, 401, 402, 409,

B 118, 119, 124, 128, 131, 132, 133, 135, 144, 326, 384, 386, 387, 389, 390, 393, 394, 396, 397, 398, 400, 401, 402, 404,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 82, 83, 84, 127, 136, 146, 149, 194, 196, 197, 199, 200, 211, 212, 216, 220, 263, 265, 267, 269, 270, 271, 273, 275, 277, 293, 294, 297, 298, 300, 302, 305, 306, 309, 310, 313, 314, 317, 323, 327, 328, 330, 348, 352, 353, 354, 355, 357, 358, 359, 360, 361, 362, 368, 379, 381, 383,

B 82, 83, 84, 127, 136, 146, 149, 194, 196, 197, 199, 200, 211, 212, 216, 220, 263, 265, 267, 269, 270, 271, 272, 273, 275, 293, 294, 297, 298, 300, 302, 305, 306, 309, 310, 313, 314, 317, 323, 327, 328, 330, 348, 352, 353, 354, 355, 357, 358, 359, 360, 361, 362, 368, 381, 382, 383,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:1VL2 B:1VL2

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 1VL2.ali
atm file: 1VL2.atm
cof file: 1VL2.cof
hbd file: 1VL2.hbd
html file: 1VL2.html
pdb file: 1VL2.pdb
ps file: 1VL2.ps
psa file: 1VL2.psa
rtf file: 1VL2.rtf
sst file: 1VL2.sst
tem file: 1VL2.tem