Pfam Domains mapped on to the structure: 1VGE

No.	Chain ID	Pfam ID	Pfam Description	Linkout - Pfam	Linkout - CDD
1	L	PF13927	Immunoglobulin domain	PF13927	PF13927
2	L	PF13927	Immunoglobulin domain	PF13927	PF13927

Conserved Domain Database Superfamily Annotations: 1VGE

No.	PDB ID	PSSM ID	CDD Accession	Superfamily Short Name	Linkout - CDD
1	1VGE	143182	cd04981	IgV_H -	cl11960
2	1VGE	212623	cl11960	Ig	superfamily - -
3	1VGE	143186	cd04985	IgC_CH1 -	cl11960
4	1VGE	212623	cl11960	Ig	superfamily - -
5	1VGE	212623	cl11960	Ig	superfamily - -

Structural Details of PDB entry 1VGE PDBid Chains Hinge Swapped Domain 1VGE H,L H:100-112,L:91-98 H:1-99,L:1-90 Swapped-domain interface residues and interactions: Chains Residues H 40, 45, 46, 48, 60, 62, 64, 96, 108, 110, 112, 113, 114, L 1, 4, 36, 38, 43, 44, 46, 49, 55, 87, 89, 95, 96, 98, 99, 100, Non-swapped-domain interface residues and interactions: Chains Residues H 102, 105, 106, 107, 109, 131, 132, 133, 134, 136, 137, 138, 144, 145, 146, 150, 152, 170, 173, 174, 175, 176, 178, 179, 180, 188, 190, 192, 218, 223, L 91, 92, 94, 116, 118, 119, 121, 123, 124, 127, 129, 131, 133, 135, 137, 138, 160, 161, 162, 163, 164, 167, 169, 174, 176, 178, 180, 213, 214,

Swapped domains are represented using trasperent spheres. Non-swapped part is represented using light color and cartoon representation. Hinge region is shown in yellow color.

Mutations in critical regions:

Chains	Hinge	Domain swapped interface	Non-swapped interface	Swapped Domain
H	No mutation	No mutation	No mutation	No mutation
L	PHE(91)ALA, TYR(94)PHE, LEU(96)TYR,	MET(4)-, GLU(55)GLN, LEU(96)TYR, GLY(100)GLN,	PHE(91)ALA, TYR(94)PHE,	VAL(3)-, MET(4)-, LEU(11)VAL, ASN(20)THR, ALA(22)THR, ALA(32)TRP, ARG(45)LYS, ASP(50)SER, ASN(53)SER, GLU(55)GLN, THR(72)SER, PHE(83)SER, ILE(85)THR,

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

H:1VGE

JOY Structural annotation for hinge hinge and swapped domain:

Hinge	Swapped domain

JOY output:

ali file:	1VGE.ali
atm file:	1VGE.atm
cof file:	1VGE.cof
hbd file:	1VGE.hbd
html file:	1VGE.html
pdb file:	1VGE.pdb
ps file:	1VGE.ps
psa file:	1VGE.psa
rtf file:	1VGE.rtf
sst file:	1VGE.sst
tem file:	1VGE.tem