Pfam Domains mapped on to the structure: 1V8B

No.	Chain ID	Pfam ID	Pfam Description	Linkout - Pfam	Linkout - CDD
1	A	PF05221	S-adenosyl-L-homocysteine hydrolase	PF05221	PF05221
2	A	PF00670	S-adenosyl-L-homocysteine hydrolase, NAD binding domain	PF00670	PF00670
3	A	PF07991	Acetohydroxy acid isomeroreductase, catalytic domain	PF07991	PF07991

Conserved Domain Database Superfamily Annotations: 1V8B

No.	PDB ID	PSSM ID	CDD Accession	Superfamily Short Name	Linkout - CDD
1	1V8B	29522	cd00401	AdoHcyase -	cl09931
2	1V8B	212616	cl09931	NADB_Rossmann	superfamily - -
3	1V8B	212616	cl09931	NADB_Rossmann	superfamily - -

Structural Details of PDB entry 1V8B PDBid Chains Hinge Swapped Domain 1V8B A,B A:450-458,B:450-458 A:459-479,B:459-479 Swapped-domain interface residues and interactions: Chains Residues A 289, 322, 323, 459, 460, 463, 464, 465, 472, 473, 474, 475, 476, 477, 478, B 289, 322, 323, 459, 460, 463, 464, 465, 472, 473, 474, 475, 476, 477, 478, Non-swapped-domain interface residues and interactions: Chains Residues A 206, 209, 210, 226, 228, 231, 232, 233, 237, 240, 266, 267, 270, 286, 287, 288, 290, 291, 292, 293, 294, 295, 297, 298, 299, 302, 303, 304, 305, 308, 321, 324, 327, 345, 401, 402, 405, 432, 439, 442, 443, 446, 449, 450, 451, 452, 453, 454, 456, 457, B 206, 209, 210, 226, 228, 231, 232, 233, 237, 240, 266, 267, 270, 286, 287, 288, 290, 291, 292, 293, 294, 295, 297, 298, 299, 303, 304, 305, 308, 321, 324, 327, 345, 401, 402, 405, 432, 439, 442, 443, 446, 449, 450, 451, 452, 453, 454, 456, 457,

Swapped domains are represented using trasperent spheres. Non-swapped part is represented using light color and cartoon representation. Hinge region is shown in yellow color.

Mutations in critical regions:

Chains	Hinge	Domain swapped interface	Non-swapped interface	Swapped Domain
A	No mutation	No mutation	No mutation	No mutation
B	No mutation	No mutation	No mutation	No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:1V8B

B:1V8B

JOY Structural annotation for hinge hinge and swapped domain:

Hinge	Swapped domain

JOY output:

ali file:	1V8B.ali
atm file:	1V8B.atm
cof file:	1V8B.cof
hbd file:	1V8B.hbd
html file:	1V8B.html
pdb file:	1V8B.pdb
ps file:	1V8B.ps
psa file:	1V8B.psa
rtf file:	1V8B.rtf
sst file:	1V8B.sst
tem file:	1V8B.tem