3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 1UM4

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 L PF13895 Immunoglobulin domain PF13895 PF13895

2 L PF13895 Immunoglobulin domain PF13895 PF13895

3 L PF13927 Immunoglobulin domain PF13927 PF13927

4 L PF13927 Immunoglobulin domain PF13927 PF13927

5 L PF00047 Immunoglobulin domain PF00047 PF00047

6 H PF13927 Immunoglobulin domain PF13927 PF13927

Conserved Domain Database Superfamily Annotations: 1UM4

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 1UM4 212623 cl11960 Ig superfamily - -

2 1UM4 143186 cd04985 IgC_CH1 - cl11960

3 1UM4 212623 cl11960 Ig superfamily - -

4 1UM4 212623 cl11960 Ig superfamily - -

Structural Details of PDB entry 1UM4

Structural Details of PDB entry 1UM4

PDBid Chains Hinge Swapped Domain

1UM4 H,L H:43-46,L:43-46 H:3-42,L:2-42

Swapped-domain interface residues and interactions:

Chains Residues
H 4, 36, 38, 40,

L 3, 36, 38, 40,

Non-swapped-domain interface residues and interactions:

Chains Residues
H 43, 45, 46, 48, 51, 60, 62, 64, 96, 103, 104, 105, 106, 107, 109, 128, 129, 130, 131, 133, 134, 135, 136, 138, 143, 147, 149, 167, 170, 172, 173, 175, 177, 185, 187, 189, 215,

L 44, 45, 46, 48, 51, 89, 93, 96, 97, 98, 100, 102, 105, 116, 118, 119, 120, 121, 123, 125, 126, 129, 131, 133, 135, 137, 139, 140, 162, 163, 164, 165, 166, 169, 171, 176, 178, 180, 182, 209, 210, 211, 217, 218, 220,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

H No mutation No mutation No mutation No mutation

L No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

H:1UM4

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 1UM4.ali
atm file: 1UM4.atm
cof file: 1UM4.cof
hbd file: 1UM4.hbd
html file: 1UM4.html
pdb file: 1UM4.pdb
ps file: 1UM4.ps
psa file: 1UM4.psa
rtf file: 1UM4.rtf
sst file: 1UM4.sst
tem file: 1UM4.tem