3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 1TYO

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF00180 Isocitrate/isopropylmalate dehydrogenase PF00180 PF00180

Conserved Domain Database Superfamily Annotations: 1TYO

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 1TYO 212218 cl00445 Iso_dh superfamily - -

2 1TYO 212218 cl00445 Iso_dh superfamily - -

Structural Details of PDB entry 1TYO

Structural Details of PDB entry 1TYO

PDBid Chains Hinge Swapped Domain

1TYO A,B A:196-197,B:196-197 A:198-300,B:198-300

Swapped-domain interface residues and interactions:

Chains Residues
A 117, 118, 145, 146, 147, 148, 149, 163, 165, 166, 168, 169, 170, 171, 172, 173, 177, 180, 181, 184, 185, 188, 189, 191, 193, 194, 196, 197, 198, 199, 200, 201, 202, 203, 204, 205, 206, 207, 233, 235, 236, 237, 238, 239, 240, 247, 286, 287, 290, 291, 294, 295, 296, 308, 309, 311, 312, 315, 316, 319, 320, 324, 401, 432,

B 119, 145, 146, 147, 148, 149, 163, 165, 166, 168, 169, 170, 171, 172, 173, 177, 180, 181, 184, 185, 188, 189, 191, 193, 194, 196, 197, 198, 199, 200, 201, 202, 203, 204, 205, 206, 207, 233, 235, 236, 237, 238, 239, 240, 247, 286, 287, 290, 291, 294, 295, 308, 309, 311, 312, 315, 316, 319, 320, 324, 401,

Non-swapped-domain interface residues and interactions:

Chains Residues

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:1TYO

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 1TYO.ali
atm file: 1TYO.atm
cof file: 1TYO.cof
hbd file: 1TYO.hbd
html file: 1TYO.html
pdb file: 1TYO.pdb
ps file: 1TYO.ps
psa file: 1TYO.psa
rtf file: 1TYO.rtf
sst file: 1TYO.sst
tem file: 1TYO.tem