Pfam Domains mapped on to the structure: 1TW3

No.	Chain ID	Pfam ID	Pfam Description	Linkout - Pfam	Linkout - CDD
1	A	PF00891	O-methyltransferase	PF00891	PF00891
2	A	PF05175	Methyltransferase small domain	PF05175	PF05175
3	A	PF12847	Methyltransferase domain	PF12847	PF12847
4	A	PF08242	Methyltransferase domain	PF08242	PF08242

Conserved Domain Database Superfamily Annotations: 1TW3

No.	PDB ID	PSSM ID	CDD Accession	Superfamily Short Name	Linkout - CDD
1	1TW3	100107	AdoMet_MTases	N	cl16911
2	1TW3	212630	AdoMet_MTases	superfamily	N -
3	1TW3	212630	AdoMet_MTases	superfamily	N -

Structural Details of PDB entry 1TW3 PDBid Chains Hinge Swapped Domain 1TW3 A,B A:24-26,B:24-26 A:12-23,B:12-23 Swapped-domain interface residues and interactions: Chains Residues A 12, 13, 15, 16, 18, 19, 20, 21, 22, 23, 27, 28, 31, 32, 89, 90, 339, 340, B 12, 13, 15, 16, 17, 18, 19, 20, 21, 22, 23, 27, 28, 31, 32, 89, 90, 340, Non-swapped-domain interface residues and interactions: Chains Residues A 24, 25, 26, 29, 30, 33, 36, 37, 58, 59, 60, 62, 63, 65, 66, 67, 69, 70, 72, 73, 74, 76, 85, 93, 94, 98, 100, 102, 106, 108, 116, 117, 119, 120, 122, 123, 126, 127, 128, 129, 130, 288, 291, 292, 294, 296, 297, 298, 300, 301, 304, 310, 316, 338, 351, B 24, 25, 26, 29, 30, 33, 36, 37, 58, 59, 60, 62, 63, 65, 66, 67, 69, 70, 72, 73, 74, 76, 79, 93, 98, 100, 102, 106, 108, 116, 117, 119, 120, 122, 123, 126, 127, 128, 129, 130, 288, 291, 292, 294, 296, 297, 298, 300, 301, 304, 309, 310, 316, 339,

Swapped domains are represented using trasperent spheres. Non-swapped part is represented using light color and cartoon representation. Hinge region is shown in yellow color.

Mutations in critical regions:

Chains	Hinge	Domain swapped interface	Non-swapped interface	Swapped Domain
A	No mutation	No mutation	No mutation	No mutation
B	No mutation	No mutation	No mutation	No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:1TW3

B:1TW3

JOY Structural annotation for hinge hinge and swapped domain:

Hinge	Swapped domain

JOY output:

ali file:	1TW3.ali
atm file:	1TW3.atm
cof file:	1TW3.cof
hbd file:	1TW3.hbd
html file:	1TW3.html
pdb file:	1TW3.pdb
ps file:	1TW3.ps
psa file:	1TW3.psa
rtf file:	1TW3.rtf
sst file:	1TW3.sst
tem file:	1TW3.tem