3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 1T3F

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF13895 Immunoglobulin domain PF13895 PF13895

2 A PF13895 Immunoglobulin domain PF13895 PF13895

3 A PF13927 Immunoglobulin domain PF13927 PF13927

4 A PF13927 Immunoglobulin domain PF13927 PF13927

5 A PF00047 Immunoglobulin domain PF00047 PF00047

6 B PF13927 Immunoglobulin domain PF13927 PF13927

Conserved Domain Database Superfamily Annotations: 1T3F

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 1T3F 143182 cd04981 IgV_H - cl11960

2 1T3F 212623 cl11960 Ig superfamily - -

3 1T3F 143186 cd04985 IgC_CH1 - cl11960

4 1T3F 212623 cl11960 Ig superfamily - -

5 1T3F 212623 cl11960 Ig superfamily - -

Structural Details of PDB entry 1T3F

Structural Details of PDB entry 1T3F

PDBid Chains Hinge Swapped Domain

1T3F A,B A:41-45,B:42-46 A:1-40,B:2-41

Swapped-domain interface residues and interactions:

Chains Residues
A 32, 34, 36, 38,

B 39, 102, 103,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 41, 43, 44, 46, 49, 55, 87, 91, 94, 95, 96, 98, 100, 116, 117, 118, 119, 121, 123, 124, 129, 131, 133, 135, 137, 138, 160, 161, 162, 163, 164, 167, 174, 176, 178, 180, 207, 213, 214,

B 44, 45, 47, 50, 61, 95, 104, 105, 107, 108, 109, 125, 126, 127, 128, 129, 131, 134, 135, 141, 145, 147, 166, 168, 169, 170, 171, 173, 174, 175, 183, 185, 187, 213, 218, 219,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:1T3F B:1T3F

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 1T3F.ali
atm file: 1T3F.atm
cof file: 1T3F.cof
hbd file: 1T3F.hbd
pdb file: 1T3F.pdb
psa file: 1T3F.psa
sst file: 1T3F.sst