Pfam Domains mapped on to the structure: 1T2Q

No.	Chain ID	Pfam ID	Pfam Description	Linkout - Pfam	Linkout - CDD
1	L	PF13927	Immunoglobulin domain	PF13927	PF13927
2	L	PF00047	Immunoglobulin domain	PF00047	PF00047

Conserved Domain Database Superfamily Annotations: 1T2Q

No.	PDB ID	PSSM ID	CDD Accession	Superfamily Short Name	Linkout - CDD
1	1T2Q	143182	cd04981	IgV_H -	cl11960
2	1T2Q	212623	cl11960	Ig	superfamily - -
3	1T2Q	212623	cl11960	Ig	superfamily - -
4	1T2Q	212623	cl11960	Ig	superfamily - -

Structural Details of PDB entry 1T2Q PDBid Chains Hinge Swapped Domain 1T2Q H,L H:43-47,L:47-51 H:1-42,L:2-46 Swapped-domain interface residues and interactions: Chains Residues H 36, 40, 103, 104, 105, L 38, 40, 42, 44, Non-swapped-domain interface residues and interactions: Chains Residues H 45, 46, 48, 59, 61, 62, 95, 100, 102, 106, 107, 109, 110, 128, 129, 130, 131, 132, 133, 134, 143, 145, 147, 149, 170, 171, 172, 173, 175, 176, 177, 184, 186, 214, 219, L 49, 50, 52, 55, 56, 61, 93, 95, 97, 100, 101, 102, 104, 120, 122, 123, 124, 125, 126, 127, 129, 130, 133, 137, 139, 141, 143, 144, 166, 167, 168, 169, 170, 173, 180, 182, 184, 186, 218,

Swapped domains are represented using trasperent spheres. Non-swapped part is represented using light color and cartoon representation. Hinge region is shown in yellow color.

Mutations in critical regions:

Chains	Hinge	Domain swapped interface	Non-swapped interface	Swapped Domain
H	No mutation	No mutation	No mutation	No mutation
L	No mutation	No mutation	No mutation	No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

H:1T2Q

JOY Structural annotation for hinge hinge and swapped domain:

Hinge	Swapped domain

JOY output:

ali file:	1T2Q.ali
atm file:	1T2Q.atm
cof file:	1T2Q.cof
hbd file:	1T2Q.hbd
html file:	1T2Q.html
pdb file:	1T2Q.pdb
ps file:	1T2Q.ps
psa file:	1T2Q.psa
rtf file:	1T2Q.rtf
sst file:	1T2Q.sst
tem file:	1T2Q.tem