3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 1SS4

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PF00903 PF00903

2 A PF13669 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PF13669 PF13669

3 A PF12681 Glyoxalase-like domain PF12681 PF12681

Conserved Domain Database Superfamily Annotations: 1SS4

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 1SS4 211359 cd08353 Glo_EDI_BRP_like_7 - cl14632

2 1SS4 211465 cl14632 Glo_EDI_BRP_like superfamily - -

3 1SS4 211465 cl14632 Glo_EDI_BRP_like superfamily - -

Structural Details of PDB entry 1SS4

Structural Details of PDB entry 1SS4

PDBid Chains Hinge Swapped Domain

1SS4 A,B A:82-91,B:82-91 A:92-148,B:92-148

Swapped-domain interface residues and interactions:

Chains Residues
A 4, 5, 6, 7, 8, 10, 11, 12, 13, 14, 15, 43, 46, 47, 48, 49, 82, 83, 84, 92, 93, 94, 95, 96, 98, 99, 100, 101, 102, 105, 109, 118, 119, 120, 122, 124, 130, 132, 139, 146, 148,

B 4, 5, 6, 7, 8, 10, 11, 12, 13, 14, 15, 43, 46, 47, 48, 49, 82, 83, 84, 92, 93, 94, 95, 96, 98, 99, 100, 101, 102, 105, 109, 118, 119, 120, 122, 123, 124, 130, 132, 139, 146,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 0, 3, 17, 29, 30, 50, 62, 63, 64, 66, 67, 70, 74, 77, 79, 80, 81, 86, 87, 88, 89, 90, 91,

B 17, 29, 30, 32, 50, 62, 63, 64, 66, 67, 70, 74, 77, 79, 80, 81, 86, 87, 88, 89, 90, 91,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:1SS4 B:1SS4

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 1SS4.ali
atm file: 1SS4.atm
cof file: 1SS4.cof
hbd file: 1SS4.hbd
html file: 1SS4.html
pdb file: 1SS4.pdb
ps file: 1SS4.ps
psa file: 1SS4.psa
rtf file: 1SS4.rtf
sst file: 1SS4.sst
tem file: 1SS4.tem