3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 1S8O

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF13419 Haloacid dehalogenase-like hydrolase PF13419 PF13419

2 A PF12695 Alpha/beta hydrolase family PF12695 PF12695

3 A PF12697 Alpha/beta hydrolase family PF12697 PF12697

4 A PF00561 alpha/beta hydrolase fold PF00561 PF00561

Conserved Domain Database Superfamily Annotations: 1S8O

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 1S8O 119389 HAD_like N cl11391

2 1S8O 212620 HAD_like superfamily N -

3 1S8O 211462 Esterase_lipase superfamily NC -

4 1S8O 211462 Esterase_lipase superfamily NC -

5 1S8O 211462 Esterase_lipase superfamily NC -

6 1S8O 211462 Esterase_lipase superfamily NC -

Structural Details of PDB entry 1S8O

Structural Details of PDB entry 1S8O

PDBid Chains Hinge Swapped Domain

1S8O A,B A:219-234,B:219-234 A:4-218,B:4-218

Swapped-domain interface residues and interactions:

Chains Residues
A 56, 57, 59, 61, 62, 127, 128, 129, 131, 133, 134, 137, 138, 141, 144, 155, 322, 327, 328, 348, 349, 350, 351, 478, 481, 482, 485, 486,

B 56, 57, 59, 61, 62, 127, 128, 129, 131, 133, 134, 137, 138, 141, 144, 155, 322, 327, 328, 348, 349, 350, 351, 478, 481, 482, 485, 486,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 235, 236, 237, 238, 239, 240, 241, 242, 243, 254, 255, 256, 257, 287, 323, 324, 325, 326, 347, 483, 548,

B 235, 236, 237, 238, 239, 240, 241, 242, 243, 254, 255, 256, 257, 287, 323, 324, 325, 326, 347, 483,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:1S8O B:1S8O

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 1S8O.ali
atm file: 1S8O.atm
cof file: 1S8O.cof
hbd file: 1S8O.hbd
html file: 1S8O.html
pdb file: 1S8O.pdb
ps file: 1S8O.ps
psa file: 1S8O.psa
rtf file: 1S8O.rtf
sst file: 1S8O.sst
tem file: 1S8O.tem