Pfam Domains mapped on to the structure: 1S5H

No.	Chain ID	Pfam ID	Pfam Description	Linkout - Pfam	Linkout - CDD
1	A	PF13895	Immunoglobulin domain	PF13895	PF13895
2	A	PF13927	Immunoglobulin domain	PF13927	PF13927
3	B	PF13895	Immunoglobulin domain	PF13895	PF13895
4	C	PF07885	Ion channel	PF07885	PF07885
5	C	PF00520	Ion transport protein	PF00520	PF00520

Conserved Domain Database Superfamily Annotations: 1S5H

No.	PDB ID	PSSM ID	CDD Accession	Superfamily Short Name	Linkout - CDD
1	1S5H	209363	Ion_trans_2	superfamily	N -

Structural Details of PDB entry 1S5H PDBid Chains Hinge Swapped Domain 1S5H A,B A:41-45,B:42-46 A:1-40,B:1-41 Swapped-domain interface residues and interactions: Chains Residues A 1, 34, 36, 38, B 35, 39, 104, Non-swapped-domain interface residues and interactions: Chains Residues A 42, 43, 44, 46, 49, 50, 87, 89, 91, 94, 95, 96, 98, 100, 114, 116, 117, 118, 119, 120, 121, 123, 124, 127, 131, 133, 135, 137, 138, 160, 161, 162, 164, 167, 174, 176, 178, 180, 209, 211, B 44, 45, 47, 50, 59, 61, 62, 63, 95, 99, 102, 103, 105, 106, 108, 109, 110, 127, 128, 129, 130, 131, 132, 134, 136, 142, 146, 148, 169, 171, 172, 174, 176, 181, 183, 185, 213, 218,

Swapped domains are represented using trasperent spheres. Non-swapped part is reprented using light color and cartoon reprentation. Hinge region is shown in yellow color.

Mutations in critical regions:

Chains	Hinge	Domain swapped interface	Non-swapped interface	Swapped Domain
A	No mutation	No mutation	No mutation	No mutation
B	No mutation	No mutation	No mutation	No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

3:1S5H

A:1S5H

B:1S5H

JOY Structural annotation for hinge hinge and swapped domain:

Hinge	Swapped domain

JOY output:

ali file:	1S5H.ali
atm file:	1S5H.atm
cof file:	1S5H.cof
hbd file:	1S5H.hbd
html file:	1S5H.html
pdb file:	1S5H.pdb
ps file:	1S5H.ps
psa file:	1S5H.psa
rtf file:	1S5H.rtf
sst file:	1S5H.sst
tem file:	1S5H.tem