3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 1S3K

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 L PF13895 Immunoglobulin domain PF13895 PF13895

2 L PF13895 Immunoglobulin domain PF13895 PF13895

3 L PF13927 Immunoglobulin domain PF13927 PF13927

4 L PF13927 Immunoglobulin domain PF13927 PF13927

5 L PF00047 Immunoglobulin domain PF00047 PF00047

6 H PF13927 Immunoglobulin domain PF13927 PF13927

Conserved Domain Database Superfamily Annotations: 1S3K

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 1S3K 143182 cd04981 IgV_H - cl11960

2 1S3K 212623 cl11960 Ig superfamily - -

3 1S3K 143186 cd04985 IgC_CH1 - cl11960

4 1S3K 212623 cl11960 Ig superfamily - -

5 1S3K 212623 cl11960 Ig superfamily - -

Structural Details of PDB entry 1S3K

Structural Details of PDB entry 1S3K

PDBid Chains Hinge Swapped Domain

1S3K H,L H:42-45,L:46-49 H:1-41,L:1-45

Swapped-domain interface residues and interactions:

Chains Residues
H 39,

L 37, 39, 41, 43,

Non-swapped-domain interface residues and interactions:

Chains Residues
H 44, 45, 47, 50, 59, 61, 95, 100, 102, 103, 104, 105, 106, 107, 108, 109, 110, 128, 129, 130, 131, 141, 143, 147, 149, 170, 172, 173, 175, 176, 177, 185, 187, 189, 215,

L 48, 49, 51, 54, 55, 60, 92, 94, 96, 99, 100, 101, 103, 121, 123, 124, 126, 128, 129, 132, 134, 136, 138, 140, 142, 143, 165, 166, 167, 168, 169, 170, 172, 179, 181, 183, 185, 216,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

H No mutation No mutation No mutation No mutation

L No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

H:1S3K

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 1S3K.ali
atm file: 1S3K.atm
cof file: 1S3K.cof
hbd file: 1S3K.hbd
html file: 1S3K.html
pdb file: 1S3K.pdb
ps file: 1S3K.ps
psa file: 1S3K.psa
rtf file: 1S3K.rtf
sst file: 1S3K.sst
tem file: 1S3K.tem