3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 1RZ7

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 L PF13927 Immunoglobulin domain PF13927 PF13927

2 L PF13927 Immunoglobulin domain PF13927 PF13927

3 L PF00047 Immunoglobulin domain PF00047 PF00047

4 H PF13927 Immunoglobulin domain PF13927 PF13927

Conserved Domain Database Superfamily Annotations: 1RZ7

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 1RZ7 143182 cd04981 IgV_H - cl11960

2 1RZ7 212623 cl11960 Ig superfamily - -

3 1RZ7 143186 cd04985 IgC_CH1 - cl11960

4 1RZ7 212623 cl11960 Ig superfamily - -

5 1RZ7 212623 cl11960 Ig superfamily - -

Structural Details of PDB entry 1RZ7

Structural Details of PDB entry 1RZ7

PDBid Chains Hinge Swapped Domain

1RZ7 H,L H:41-46,L:40-45 H:1-40,L:2-39

Swapped-domain interface residues and interactions:

Chains Residues
H 35, 39,

L 32, 34, 36, 38,

Non-swapped-domain interface residues and interactions:

Chains Residues
H 44, 45, 47, 50, 58, 61, 64, 91, 99, 100, 101, 103, 104, 122, 123, 124, 125, 127, 128, 129, 130, 131, 132, 137, 141, 143, 161, 162, 164, 165, 166, 167, 169, 170, 171, 179, 181, 183, 209,

L 43, 44, 46, 49, 50, 55, 87, 89, 91, 94, 96, 98, 100, 114, 116, 117, 118, 119, 121, 123, 124, 131, 133, 135, 137, 138, 160, 161, 162, 163, 164, 167, 169, 174, 176, 178, 180, 207, 208, 213,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

H No mutation No mutation No mutation No mutation

L No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

H:1RZ7

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 1RZ7.ali
atm file: 1RZ7.atm
cof file: 1RZ7.cof
hbd file: 1RZ7.hbd
html file: 1RZ7.html
pdb file: 1RZ7.pdb
ps file: 1RZ7.ps
psa file: 1RZ7.psa
rtf file: 1RZ7.rtf
sst file: 1RZ7.sst
tem file: 1RZ7.tem