Pfam Domains mapped on to the structure: 1REW

No.	Chain ID	Pfam ID	Pfam Description	Linkout - Pfam	Linkout - CDD
1	A	PF00019	Transforming growth factor beta like domain	PF00019	PF00019
2	C	PF01064	Activin types I and II receptor domain	PF01064	PF01064

Gene Ontology Annotations: 1REW

No.	GO ID	GO Description	Linkout - AmiGO
1	GO:0016020	membrane	GO:0016020

Conserved Domain Database Superfamily Annotations: 1REW

No.	PDB ID	PSSM ID	CDD Accession	Superfamily Short Name	Linkout - CDD
1	1REW	189827	cl15639	Activin_recp	superfamily - -

Structural Details of PDB entry 1REW PDBid Chains Hinge Swapped Domain 1REW A,B A:58-70,B:58-70 A:71-114,B:71-114 Swapped-domain interface residues and interactions: Chains Residues A 58, 59, 60, 74, 75, 78, 80, 81, 84, 103, 104, 105, 106, 108, 114, B 58, 59, 60, 74, 75, 78, 80, 81, 84, 103, 104, 105, 106, 108, Non-swapped-domain interface residues and interactions: Chains Residues A 19, 21, 25, 26, 28, 38, 40, 42, 43, 44, 63, 64, 66, 67, 70, B 19, 21, 26, 28, 38, 40, 42, 43, 44, 63, 64, 66, 67, 70,

Swapped domains are represented using trasperent spheres. Non-swapped part is represented using light color and cartoon representation. Hinge region is shown in yellow color.

Mutations in critical regions:

Chains	Hinge	Domain swapped interface	Non-swapped interface	Swapped Domain
A	No mutation	No mutation	No mutation	No mutation
B	No mutation	No mutation	No mutation	No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:1REW

B:1REW

JOY Structural annotation for hinge hinge and swapped domain:

Hinge	Swapped domain

JOY output:

ali file:	1REW.ali
atm file:	1REW.atm
cof file:	1REW.cof
hbd file:	1REW.hbd
html file:	1REW.html
pdb file:	1REW.pdb
ps file:	1REW.ps
psa file:	1REW.psa
rtf file:	1REW.rtf
sst file:	1REW.sst
tem file:	1REW.tem