Pfam Domains mapped on to the structure: 1R8E

No.	Chain ID	Pfam ID	Pfam Description	Linkout - Pfam	Linkout - CDD
1	A	PF13411	MerR HTH family regulatory protein	PF13411	PF13411
2	A	PF00376	MerR family regulatory protein	PF00376	PF00376

Gene Ontology Annotations: 1R8E

No.	GO ID	GO Description	Linkout - AmiGO
1	GO:0006355	regulation of transcription, DNA-dependent	GO:0006355

Conserved Domain Database Superfamily Annotations: 1R8E

No.	PDB ID	PSSM ID	CDD Accession	Superfamily Short Name	Linkout - CDD
1	1R8E	133382	cd01107	HTH_BmrR -	cl02600
2	1R8E	207663	cl02600	HTH_MerR-SF	superfamily - -
3	1R8E	207387	cl01368	GyrI-like	superfamily - -
4	1R8E	207387	cl01368	GyrI-like	superfamily - -

Structural Details of PDB entry 1R8E PDBid Chains Hinge Swapped Domain 1R8E A,B A:98-101,B:98-101 A:1-97,B:1-97 Swapped-domain interface residues and interactions: Chains Residues A 4, 6, 13, 14, 16, 47, 48, 50, 51, 52, 54, 55, 57, 58, 61, 62, 73, 74, 75, 77, 78, 80, 81, 84, 85, 88, 91, 92, 94, 95, 97, 98, 102, 105, 109, 148, 149, 150, 153, 164, 165, 166, 258, 259, 260, 261, B 4, 6, 13, 14, 16, 47, 48, 50, 51, 52, 54, 55, 57, 58, 61, 62, 73, 74, 75, 77, 78, 80, 81, 84, 85, 88, 91, 92, 94, 95, 97, 98, 102, 105, 109, 148, 149, 150, 153, 164, 165, 166, 258, 259, 260, 261, Non-swapped-domain interface residues and interactions: Chains Residues A 99, 101, 106, 108, 112, 113, 115, 116, 156, 157, 160, 163, 170, 256, 257, 262, 263, 266, 268, 277, B 99, 101, 106, 108, 112, 113, 115, 116, 156, 157, 160, 163, 170, 256, 257, 262, 263, 266, 268,

Swapped domains are represented using trasperent spheres. Non-swapped part is reprented using light color and cartoon reprentation. Hinge region is shown in yellow color.

Mutations in critical regions:

Chains	Hinge	Domain swapped interface	Non-swapped interface	Swapped Domain
A	No mutation	No mutation	No mutation	No mutation
B	No mutation	No mutation	No mutation	No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

3:1R8E

A:1R8E

B:1R8E

JOY Structural annotation for hinge hinge and swapped domain:

Hinge	Swapped domain

JOY output:

ali file:	1R8E.ali
atm file:	1R8E.atm
cof file:	1R8E.cof
hbd file:	1R8E.hbd
html file:	1R8E.html
pdb file:	1R8E.pdb
ps file:	1R8E.ps
psa file:	1R8E.psa
rtf file:	1R8E.rtf
sst file:	1R8E.sst
tem file:	1R8E.tem