3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 1P8F

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF00180 Isocitrate/isopropylmalate dehydrogenase PF00180 PF00180

Conserved Domain Database Superfamily Annotations: 1P8F

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 1P8F 212218 cl00445 Iso_dh superfamily - -

2 1P8F 212218 cl00445 Iso_dh superfamily - -

Structural Details of PDB entry 1P8F

Structural Details of PDB entry 1P8F

PDBid Chains Hinge Swapped Domain

1P8F A,B A:187-201,B:187-201 A:202-377,B:202-377

Swapped-domain interface residues and interactions:

Chains Residues
A 113, 140, 160, 164, 165, 166, 167, 190, 193, 194, 195, 196, 197, 202, 203, 204, 205, 208, 230, 232, 233, 234, 235, 236, 237, 244, 282, 283, 286, 287, 290, 291, 292, 304, 305, 307, 308, 311, 312, 315, 320,

B 113, 140, 160, 164, 165, 166, 167, 190, 193, 194, 195, 196, 197, 202, 203, 204, 205, 208, 230, 232, 233, 234, 235, 236, 237, 244, 282, 283, 286, 287, 290, 291, 292, 304, 305, 307, 308, 311, 312, 315, 320,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 110, 111, 112, 116, 123, 139, 141, 142, 156, 157, 159, 161, 162, 163, 171, 174, 175, 178, 179, 182, 183, 185, 187, 188, 189, 198, 199, 200, 201, 395, 396,

B 110, 111, 112, 116, 123, 139, 141, 142, 156, 157, 159, 161, 162, 163, 171, 174, 175, 178, 179, 182, 183, 185, 187, 188, 189, 198, 199, 200, 201, 395,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:1P8F B:1P8F

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 1P8F.ali
atm file: 1P8F.atm
cof file: 1P8F.cof
hbd file: 1P8F.hbd
html file: 1P8F.html
pdb file: 1P8F.pdb
ps file: 1P8F.ps
psa file: 1P8F.psa
rtf file: 1P8F.rtf
sst file: 1P8F.sst
tem file: 1P8F.tem