3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 1NXU

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF02615 Malate/L-lactate dehydrogenase PF02615 PF02615

Gene Ontology Annotations: 1NXU

No. GO ID GO Description Linkout - AmiGO

1 GO:0055114 oxidation-reduction process GO:0055114

Conserved Domain Database Superfamily Annotations: 1NXU

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 1NXU 207240 cl00900 Ldh_2 superfamily - -

Structural Details of PDB entry 1NXU

Structural Details of PDB entry 1NXU

PDBid Chains Hinge Swapped Domain

1NXU A,B A:145-155,B:145-155 A:2-144,B:2-144

Swapped-domain interface residues and interactions:

Chains Residues
A 71, 73, 75, 76, 78, 104, 105, 106, 108, 133, 135,

B 71, 73, 75, 76, 78, 104, 105, 106, 108, 133, 135,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 146, 147, 148, 149, 150, 151, 153, 154, 159, 161, 163, 169, 171, 174, 176, 178, 194, 195, 217, 222, 223, 224, 225, 228, 231, 232, 234, 236, 238, 239, 240, 242, 243, 245, 247, 248, 250, 251, 252, 264, 266, 268, 270, 271, 272, 280, 281, 283, 284, 287, 288, 290, 291, 292, 293, 294, 300, 302, 303, 332,

B 146, 147, 148, 149, 150, 151, 153, 159, 161, 163, 169, 171, 174, 176, 178, 194, 195, 222, 223, 224, 225, 228, 231, 232, 234, 236, 238, 239, 240, 242, 243, 245, 247, 248, 250, 251, 252, 264, 266, 268, 270, 271, 272, 276, 280, 281, 283, 284, 287, 288, 290, 291, 292, 293, 294, 300, 302, 303,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:1NXU B:1NXU

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 1NXU.ali
atm file: 1NXU.atm
cof file: 1NXU.cof
hbd file: 1NXU.hbd
html file: 1NXU.html
pdb file: 1NXU.pdb
ps file: 1NXU.ps
psa file: 1NXU.psa
rtf file: 1NXU.rtf
sst file: 1NXU.sst
tem file: 1NXU.tem