3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 1NX9

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF02129 X-Pro dipeptidyl-peptidase (S15 family) PF02129 PF02129

2 A PF08530 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF08530 PF08530

Gene Ontology Annotations: 1NX9

No. GO ID GO Description Linkout - AmiGO

1 GO:0008239 dipeptidyl-peptidase activity GO:0008239

Conserved Domain Database Superfamily Annotations: 1NX9

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 1NX9 208950 cl08482 PepX_C superfamily - -

2 1NX9 208950 cl08482 PepX_C superfamily - -

Structural Details of PDB entry 1NX9

Structural Details of PDB entry 1NX9

PDBid Chains Hinge Swapped Domain

1NX9 A,B A:62-74,B:62-74 A:50-61,B:50-61

Swapped-domain interface residues and interactions:

Chains Residues
A 52, 53, 54, 55, 56, 57, 58, 59, 60, 61,

B 52, 53, 54, 55, 56, 57, 58, 59, 60, 61,

C 159, 160, 161, 170, 258, 259, 260, 296, 297, 300, 301, 304, 311,

D 159, 160, 161, 170, 258, 259, 260, 296, 297, 300, 301, 304, 311,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 62, 65, 66, 67, 68, 69, 72, 120, 121, 122, 123, 125, 126, 128, 129, 133, 159, 160, 161, 169, 170, 172, 173, 255, 258, 259, 260, 265, 268, 269, 270, 271, 272, 273, 280, 289, 290, 291, 292, 295, 296, 297, 300, 301, 304, 305, 311, 376, 378, 384, 386, 387, 388, 392, 471, 473, 476, 483, 484, 500, 502, 503, 505, 506, 507, 508, 509, 510, 514, 553, 554, 556, 557, 559, 562, 563, 611, 666,

B 62, 65, 66, 67, 68, 69, 72, 120, 121, 122, 123, 125, 126, 128, 129, 133, 159, 160, 161, 169, 170, 172, 173, 255, 258, 259, 260, 265, 268, 269, 270, 271, 272, 280, 289, 290, 291, 292, 295, 296, 297, 300, 301, 304, 305, 311, 376, 384, 386, 387, 388, 392, 471, 473, 476, 483, 484, 500, 502, 503, 505, 506, 507, 508, 509, 510, 514, 553, 554, 556, 557, 559, 562, 563, 611, 666,

C 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 64, 65, 66, 67, 68, 69, 72, 120, 121, 122, 123, 125, 126, 128, 129, 133, 169, 172, 173, 255, 261, 265, 268, 269, 270, 271, 272, 275, 280, 289, 290, 291, 292, 295, 305, 376, 378, 384, 386, 387, 388, 392, 395, 425, 471, 473, 476, 483, 484, 500, 502, 503, 505, 506, 507, 508, 509, 510, 514, 553, 554, 556, 557, 559, 562, 563, 611, 666,

D 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 64, 65, 66, 67, 68, 69, 72, 120, 121, 122, 123, 125, 126, 128, 129, 133, 169, 172, 173, 255, 261, 265, 268, 269, 270, 271, 272, 280, 289, 290, 291, 292, 295, 305, 376, 378, 384, 386, 387, 388, 392, 395, 471, 473, 476, 483, 484, 500, 502, 503, 505, 506, 507, 508, 509, 510, 553, 554, 556, 557, 559, 562, 563, 611,

Swapped domains are represented using trasperent spheres.
Non-swapped part is reprented using light color and cartoon reprentation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

3:1NX9 A:1NX9 D:1NX9

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 1NX9.ali
atm file: 1NX9.atm
pdb file: 1NX9.pdb
psa file: 1NX9.psa
sst file: 1NX9.sst