3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 1N7M

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 H PF13895 Immunoglobulin domain PF13895 PF13895

2 H PF13895 Immunoglobulin domain PF13895 PF13895

3 H PF13927 Immunoglobulin domain PF13927 PF13927

4 H PF13927 Immunoglobulin domain PF13927 PF13927

5 H PF00047 Immunoglobulin domain PF00047 PF00047

6 L PF13895 Immunoglobulin domain PF13895 PF13895

7 L PF13927 Immunoglobulin domain PF13927 PF13927

Conserved Domain Database Superfamily Annotations: 1N7M

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 1N7M 143182 cd04981 IgV_H - cl11960

2 1N7M 212623 cl11960 Ig superfamily - -

3 1N7M 143186 cd04985 IgC_CH1 - cl11960

4 1N7M 212623 cl11960 Ig superfamily - -

5 1N7M 212623 cl11960 Ig superfamily - -

Structural Details of PDB entry 1N7M

Structural Details of PDB entry 1N7M

PDBid Chains Hinge Swapped Domain

1N7M H,L H:161-163,L:167-169 H:164-169,L:170-160

Swapped-domain interface residues and interactions:

Chains Residues
H 164, 167,

L 33, 35, 37, 39, 44, 45, 47, 59, 61, 63, 95, 100, 101, 102, 104, 105, 106, 122, 123, 124, 125, 126, 128, 132, 136, 138, 142, 144, 162, 165, 166, 167, 168, 170, 171, 172, 180, 182, 184, 210, 215,

Non-swapped-domain interface residues and interactions:

Chains Residues
H 1, 36, 38, 42, 43, 44, 46, 55, 87, 94, 95, 96, 98, 100, 116, 118, 119, 121, 122, 123, 124, 127, 129, 131, 133, 135, 137, 138, 160, 162, 163, 174, 176, 178, 180, 207, 212, 213,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

H No mutation No mutation No mutation No mutation

L No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

H:1N7M L:1N7M

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 1N7M.ali
atm file: 1N7M.atm
cof file: 1N7M.cof
hbd file: 1N7M.hbd
html file: 1N7M.html
pdb file: 1N7M.pdb
ps file: 1N7M.ps
psa file: 1N7M.psa
rtf file: 1N7M.rtf
sst file: 1N7M.sst
tem file: 1N7M.tem