3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 1MKM

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF09339 IclR helix-turn-helix domain PF09339 PF09339

2 A PF08279 HTH domain PF08279 PF08279

3 A PF13412 Winged helix-turn-helix DNA-binding PF13412 PF13412

4 A PF01614 Bacterial transcriptional regulator PF01614 PF01614

Gene Ontology Annotations: 1MKM

No. GO ID GO Description Linkout - AmiGO

1 GO:0006355 regulation of transcription, DNA-dependent GO:0006355

Conserved Domain Database Superfamily Annotations: 1MKM

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 1MKM 201890 cl08329 IclR superfamily - -

2 1MKM 212173 cl00088 HTH superfamily - -

3 1MKM 212173 cl00088 HTH superfamily - -

Structural Details of PDB entry 1MKM

Structural Details of PDB entry 1MKM

PDBid Chains Hinge Swapped Domain

1MKM A,B A:74-76,B:74-76 A:1-73,B:1-73

Swapped-domain interface residues and interactions:

Chains Residues
A 1, 2, 3, 4, 5, 7, 8, 9, 11, 12, 15, 16, 18, 36, 39, 40, 43, 44, 46, 47, 49, 51, 59, 60, 61, 62, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 204, 244, 245,

B 1, 2, 3, 4, 5, 7, 8, 9, 11, 12, 15, 16, 18, 36, 39, 40, 43, 44, 47, 49, 51, 54, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 124, 125, 126,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 74, 75, 80, 83, 205, 243, 246,

B 74, 75, 102, 107, 113, 123, 127,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:1MKM B:1MKM

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 1MKM.ali
atm file: 1MKM.atm
cof file: 1MKM.cof
hbd file: 1MKM.hbd
html file: 1MKM.html
pdb file: 1MKM.pdb
ps file: 1MKM.ps
psa file: 1MKM.psa
rtf file: 1MKM.rtf
sst file: 1MKM.sst
tem file: 1MKM.tem