Pfam Domains mapped on to the structure: 1LSS

No.	Chain ID	Pfam ID	Pfam Description	Linkout - Pfam	Linkout - CDD
1	A	PF00670	S-adenosyl-L-homocysteine hydrolase, NAD binding domain	PF00670	PF00670
2	A	PF03721	UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain	PF03721	PF03721
3	A	PF13241	Putative NAD(P)-binding	PF13241	PF13241
4	A	PF02254	TrkA-N domain	PF02254	PF02254

Gene Ontology Annotations: 1LSS

No.	GO ID	GO Description	Linkout - AmiGO
1	GO:0055114	oxidation-reduction process	GO:0055114

Conserved Domain Database Superfamily Annotations: 1LSS

No.	PDB ID	PSSM ID	CDD Accession	Superfamily Short Name	Linkout - CDD
1	1LSS	212616	NADB_Rossmann	superfamily	C -
2	1LSS	212616	NADB_Rossmann	superfamily	C -

Structural Details of PDB entry 1LSS PDBid Chains Hinge Swapped Domain 1LSS A,D,C,B A:116-117,D:116-117,C:116-117,B:116-117 A:118-132,D:118-132,C:118-132,B:118-132 Swapped-domain interface residues and interactions: Chains Residues A 10, 11, 14, 15, 118, 119, 120, 121, 122, 123, 125, 126, 127, 129, 130, 131, 132, B 10, 11, 14, 15, 118, 119, 120, 121, 122, 123, 125, 126, 127, 129, 130, 131, 132, C 10, 11, 14, 15, 118, 119, 120, 121, 122, 123, 125, 126, 127, 129, 130, 131, 132, D 10, 11, 14, 15, 116, 118, 119, 120, 121, 122, 123, 125, 126, 127, 129, 130, 131, 132, Non-swapped-domain interface residues and interactions: Chains Residues A 18, 19, 22, 24, 53, 54, 55, 68, 70, 76, 77, 78, 80, 81, 84, 85, 88, 93, 95, 99, 100, 101, 102, 103, 106, 107, 109, 110, 114, 116, B 18, 19, 22, 24, 51, 53, 54, 55, 68, 70, 75, 76, 77, 78, 80, 81, 84, 85, 88, 89, 95, 99, 101, 102, 103, 105, 106, 109, 110, 114, 116, C 3, 18, 19, 22, 24, 53, 54, 55, 56, 68, 70, 76, 77, 78, 80, 81, 84, 85, 88, 95, 99, 100, 101, 102, 103, 106, 107, 110, 114, 116, D 3, 18, 19, 22, 24, 51, 53, 54, 55, 68, 76, 77, 78, 80, 81, 84, 85, 88, 89, 95, 99, 100, 101, 102, 103, 105, 106, 107, 109, 110, 114, E 10, 11, 14, 15, 18, 19, 22, 24, 51, 53, 54, 55, 68, 70, 75, 76, 77, 78, 80, 81, 84, 85, 88, 89, 95, 99, 101, 102, 103, 105, 106, 109, 110, 114, 116, 118, 119, 120, 121, 122, 123, 125, 126, 127, 129, 130, 131, 132, F 10, 11, 14, 15, 18, 19, 22, 24, 53, 54, 55, 68, 70, 76, 77, 78, 80, 81, 84, 85, 88, 93, 95, 99, 100, 101, 102, 103, 106, 107, 109, 110, 114, 116, 118, 119, 120, 121, 122, 123, 125, 126, 127, 129, 130, 131, 132, G 3, 10, 11, 14, 15, 18, 19, 22, 24, 51, 53, 54, 55, 68, 76, 77, 78, 80, 81, 84, 85, 88, 89, 95, 99, 100, 101, 102, 103, 105, 106, 107, 109, 110, 114, 116, 118, 119, 120, 121, 122, 123, 125, 126, 127, 129, 130, 131, 132, H 3, 10, 11, 14, 15, 18, 19, 22, 24, 53, 54, 55, 56, 68, 70, 76, 77, 78, 80, 81, 84, 85, 88, 95, 99, 100, 101, 102, 103, 106, 107, 110, 114, 116, 118, 119, 120, 121, 122, 123, 125, 126, 127, 129, 130, 131,

Swapped domains are represented using trasperent spheres. Non-swapped part is represented using light color and cartoon representation. Hinge region is shown in yellow color.

Mutations in critical regions:

Chains	Hinge	Domain swapped interface	Non-swapped interface	Swapped Domain
A	No mutation	No mutation	No mutation	No mutation
D	No mutation	No mutation	No mutation	No mutation
C	No mutation	No mutation	No mutation	No mutation
B	No mutation	No mutation	No mutation	No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:1LSS

B:1LSS

C:1LSS

D:1LSS

H:1LSS

JOY Structural annotation for hinge hinge and swapped domain:

Hinge	Swapped domain

JOY output:

ali file:	1LSS.ali
atm file:	1LSS.atm
cof file:	1LSS.cof
hbd file:	1LSS.hbd
html file:	1LSS.html
pdb file:	1LSS.pdb
ps file:	1LSS.ps
psa file:	1LSS.psa
rtf file:	1LSS.rtf
sst file:	1LSS.sst
tem file:	1LSS.tem